January 2016 in “Springer eBooks” This review discusses medications used in dermatology, detailing their side effects and interactions, and reports no new clinical results.
December 2015 in “University of Birmingham Institutional Research Archive (University of Birmingham)” This study showed that regulation of adipose androgen generation via AKR1C3 may contribute to a cycle of hyperinsulinaemia and lipid accumulation in women with PCOS.
This study reported that high cholesterol levels were linked to increased prostate cancer risk, while selenium supplementation affected gene expression, suggesting nutritional and clinical factors might influence prostate cancer risk and biology.
January 2012 in “heiDOK (Heidelberg University)” In this study, researchers observed that dormant TRP-2+ melanoma cells in bone marrow can interact with CD8+ T cells in tumor-bearing ret transgenic mice, potentially influencing immune responses.
March 2022 in “International journal of pharmaceutical sciences review and research” This review examines treatment options for PCOS, highlighting the importance of managing symptoms and patient counseling, and reports no new clinical results.
March 2020 in “Journal of Laser Applications” This meta-analysis reported that photobiomodulation therapy may improve hair density and stimulate hair growth in patients with androgenic alopecia compared to sham treatments, but larger studies are needed to confirm these findings.
82 citations
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March 2016 in “Autoimmunity reviews” This review explores animal models of alopecia areata, particularly focusing on the insights they've provided into the disease's immune mechanisms and potential treatment approaches, without reporting new experimental data.
77 citations
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June 2017 in “Advances in Therapy” This review discusses recent advances and ongoing clinical trials in novel therapeutics for alopecia areata, despite the lack of current FDA-approved treatments for severe cases, and reports no new results.
2 citations
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March 2015 in “Expert opinion on orphan drugs” This review discusses recent advances in the treatment of alopecia areata, highlighting new potential therapies like JAK inhibitors and PRP, and reports no new clinical results.
1 citations
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January 2013 in “Springer eBooks” Cosmeceuticals may benefit skin health but need more research for efficacy and safety confirmation.
October 2024 in “Journal of Education Health and Sport” This article reviews treatment options for Alopecia Areata, concluding that topical corticosteroids are effective for mild cases, while systemic therapies are advised for moderate to severe cases.
July 2011 in “British Journal of Dermatology” Dermatologists give better information on pathology forms, hypersensitivity vasculitis is a common skin issue, misdiagnoses can occur, and various skin conditions are linked to loss of elastin or genetic factors.
2 citations
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September 2022 in “Dermatologic Therapy” In this study, tofacitinib showed a mixed response in treating refractory alopecia areata, with some patients experiencing complete or partial hair regrowth and others showing no response, particularly those with alopecia universalis.
May 2026 in “Journal of Neurosciences in Rural Practice” This case report describes a 23-year-old woman with alopecia areata who developed new central nervous system demyelination after starting tofacitinib therapy; while the drug was associated with this neurological event, causality is not confirmed. The demyelination was reversible upon stopping the medication and administering corticosteroids.
February 2026 in “Figshare” In this study, researchers developed a biocompatible, ROS-responsive hydrogel to deliver miR-665 locally, effectively reducing inflammatory signaling and promoting hair follicle regeneration in an alopecia areata mouse model, offering a promising approach for targeted treatment.
February 2026 in “Figshare” This study found that a newly developed biocompatible hydrogel, responsive to reactive oxygen species, enabled targeted delivery of miR-665, significantly promoting hair regeneration and reducing T-cell infiltration in a mouse model of alopecia areata, suggesting a promising strategy for treating this condition.
42 citations
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April 2021 in “JCI insight” In this study, selective inhibition of JAK3 signaling effectively prevented and reversed alopecia areata in a mouse model, while JAK2 inhibitors did not restore hair growth.
55 citations
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March 2014 in “EMBO Reports” Protein ubiquitylation is crucial for controlling stem cell functions and could be targeted for cancer treatment.
November 2022 in “Journal of Investigative Dermatology” In this study, a serum containing Silybum marianum extract, Manganese PCA, and Lespedeza capitata extract improved hair growth and prolonged the anagen phase in a human scalp skin model.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that combining Silybum marianum extract, Manganese PCA, and Lespedeza capitata extract may help improve hair growth and anchorage by targeting specific signaling pathways in human dermal papilla cells.
53 citations
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July 2018 in “Drug design, development and therapy” This review summarizes existing evidence on the efficacy and safety of JAK inhibitors for treating alopecia areata and emphasizes the need for improved topical formulations.
1 citations
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January 2023 in “SAGE open medical case reports” This case study reports the first known instance of successful rapid hair regrowth in a psoriasis patient with alopecia universalis after starting deucravacitinib, suggesting potential for TYK2 inhibitors in managing alopecia areata.
10 citations
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September 2024 in “Life” This review found that, among 103 patients treated off-label with abrocitinib for conditions beyond atopic dermatitis, favorable clinical outcomes were reported for most cases, except one isolated case involving erythematotelangiectatic rosacea.
3 citations
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November 2024 in “Clinical Research” This article discusses the immune mechanisms involved in alopecia areata, focusing on T-cell activity and cytokine-driven JAK signaling, but reports no new clinical results.
January 2025 in “International Journal of Pharmaceutics” In this study, gelatin-coated transferosomes were developed to deliver tofacitinib specifically to hair follicles, resulting in 80% hair regrowth in alopecia areata patients with recalcitrant lesions after 12 weeks of treatment.
280 citations
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January 2004 in “The EMBO Journal” AGC2-1 protein is essential for root hair growth in Arabidopsis.
277 citations
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December 2019 in “Frontiers in Immunology” This review discusses the immunological basis and development of Janus kinase inhibitors for treating skin diseases and reports no new clinical findings.
172 citations
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July 2007 in “Journal of Dermatological Science” Stat3 helps skin heal but can also cause skin diseases if overactive.
101 citations
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March 2019 in “Cell Stem Cell” This study found that Oncostatin M, via JAK-STAT5 signaling, keeps hair follicle stem cells inactive, and its removal leads to hair growth initiation in mice.
26 citations
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September 2023 in “Journal of Allergy and Clinical Immunology” Regulatory T cells help prevent autoimmunity and have potential for treating autoimmune diseases.