ROS-Responsive Hydrogel-Delivered miR-665 Targets STAT3 to Alleviate Inflammation and Promote Hair Follicle Regeneration in Alopecia Areata
February 2026
in “
Figshare
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → alopecia areata ROS-responsive hydrogel miR-665 STAT3 inflammation hair follicle regeneration PVA-TSPBA injectability ROS-dependent degradation keratinocytes dermal papilla cells imiquimod-induced AA mouse model T-cell infiltration miRNA–biomaterial strategy hair loss hydrogel microRNA biocompatible hydrogel
Studysummary In this study, researchers developed a biocompatible, ROS-responsive hydrogel to deliver miR-665 locally, effectively reducing inflammatory signaling and promoting hair follicle regeneration in an alopecia areata mouse model, offering a promising approach for targeted treatment.
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The study presents a novel treatment approach for alopecia areata (AA) using a ROS-responsive hydrogel to deliver miR-665, which targets STAT3 to reduce inflammation and promote hair follicle regeneration. The hydrogel, PVA-TSPBA, demonstrated excellent injectability and sustained release of miR-665, effectively counteracting IFN-γ-induced suppression in vitro and promoting hair regeneration in an AA mouse model. This biocompatible delivery system significantly restored follicular structure and reduced T-cell infiltration, offering a promising miRNA-biomaterial strategy for safe and durable AA treatment.
