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ROS-Responsive Hydrogel-Delivered miR-665 Targets STAT3 to Alleviate Inflammation and Promote Hair Follicle Regeneration in Alopecia Areata

research ROS-responsive hydrogel-delivered miR-665 targets STAT3 to alleviate inflammation and promote hair follicle regeneration in alopecia areata

February 2026 in “Figshare”

In this study, researchers developed a biocompatible, ROS-responsive hydrogel to deliver miR-665 locally, effectively reducing inflammatory signaling and promoting hair follicle regeneration in an alopecia areata mouse model, offering a promising approach for targeted treatment.

research ROS-responsive hydrogel-delivered miR-665 targets STAT3 to alleviate inflammation and promote hair follicle regeneration in alopecia areata

February 2026 in “Figshare”

This study found that a newly developed biocompatible hydrogel, responsive to reactive oxygen species, enabled targeted delivery of miR-665, significantly promoting hair regeneration and reducing T-cell infiltration in a mouse model of alopecia areata, suggesting a promising strategy for treating this condition.

research Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism

52 citations , May 2011 in “APOPTOSIS”

In this study, cisplatin was found to induce cell death in human hair follicle cells through hydroxyl radical generation and Bcl-2 down-regulation, suggesting potential strategies for preventing chemotherapy-induced alopecia.

research Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways

March 2026 in “Molecules”

In this laboratory study, researchers reported that Camellia sinensis seed flavonoids significantly reduced oxidative stress and inflammation in UV-irradiated skin cells by modulating key signaling pathways, highlighting its potential as a skincare ingredient for anti-inflammatory and anti-photoaging benefits.

Extracellular Matrix Degradation Products and Low-Oxygen Conditions Enhance the Regenerative Potential of Perivascular Stem Cells

research Extracellular Matrix Degradation Products and Low-Oxygen Conditions Enhance the Regenerative Potential of Perivascular Stem Cells

91 citations , July 2010 in “Tissue Engineering Part A”

This study found that low oxygen conditions and ECM degradation products increased the proliferation and migration of perivascular stem cells without altering their phenotype, suggesting potential roles in tissue repair.

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community Sometimes the hair loss was in our control the whole time

833 upvotes 11 months ago

The conversation discusses hair loss and the potential impact of diet and lifestyle changes, particularly increased protein intake, on hair health. The original poster shared their experience of improved hair appearance after weight loss and dietary changes, despite skepticism from others about lighting differences in photos and the effectiveness of diet alone without finasteride or minoxidil.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

233 upvotes 10 months ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

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Experts

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Hair Transplant Surgeon
Dr. Glen Ross, MD
Tinton Falls, NJ, United States
10+ yrs

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Dr. Glen Ross, MD