ROS-Responsive Hydrogel-Delivered miR-665 Targets STAT3 to Alleviate Inflammation and Promote Hair Follicle Regeneration in Alopecia Areata
February 2026
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Figshare
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alopecia areata ROS-responsive hydrogel miR-665 STAT3 inflammation hair follicle regeneration PVA-TSPBA injectability ROS-dependent degradation keratinocytes dermal papilla cells imiquimod-induced AA mouse model T-cell infiltration miRNA–biomaterial strategy hair loss hydrogel microRNA biocompatible hydrogel
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary This study found that a newly developed biocompatible hydrogel, responsive to reactive oxygen species, enabled targeted delivery of miR-665, significantly promoting hair regeneration and reducing T-cell infiltration in a mouse model of alopecia areata, suggesting a promising strategy for treating this condition.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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