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The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Vitamin A helps skin stem cells decide their function, aiding in hair growth and wound repair.

Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.

Nandrolone and oxandrolone could help treat male health issues like muscle loss and low testosterone.

Immune cells are crucial for hair growth and preventing hair loss.

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

The enzymes Tet2 and Tet3 are important for skin cell development and hair growth.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Immune cells are essential for early hair and skin development and healing.

New cancer treatments aim to reduce side effects and improve effectiveness.

ERULUS controls root hair growth by regulating cell wall composition and pectin activity.

Hair dyes and perms can damage hair and scalp, but using interventions can reduce harm.

ECM-inspired wound dressings can help heal chronic wounds by controlling macrophage activity.

Using focused ultrasound on the brain can help epilepsy medicine work better in rats.

Notch signalling helps skin cells differentiate and prevents tumors.

Stem cells regenerate tissues and their behavior varies by environment, suggesting the hematopoietic system model may need revision.

Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.

Topical treatments can deliver active molecules to skin stem cells, potentially helping treat skin and hair disorders, including skin cancers and hair loss.

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

Touch sensitivity in mouse skin decreases during hair growth due to changes in touch receptors.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Targeting and modifying the stem cell niche can improve regenerative therapies.

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

Edar signaling is crucial for proper hair follicle development and function.

Vitamin D receptor is crucial for skin wound healing.

EGFR helps control how hair grows and forms without needing p53 protein.