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New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.

PGD2 stops hair growth and is higher in bald men with AGA.

The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.

SCF and ET-1 together significantly increase skin pigmentation and melanin production.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

The mouse model suggests male pattern baldness may be due to an enzyme increasing DHT and higher androgen receptor levels in hair follicles.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Platelet-rich plasma is a promising and cost-effective treatment for hair and skin issues in older adults in India.

PRP is a versatile and affordable treatment for improving appearance in the elderly, with patient needs and expectations being important.

Polyomavirus A2 infection in newborn mice caused hair follicle tumors.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Estrogen therapy can reduce skin aging but has cancer risks.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.

LGR5 helps maintain corneal cell characteristics and prevents unwanted changes by controlling specific cell signaling pathways.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

The hair follicle is a great model for research to improve hair growth treatments.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.