Metformin And Malignant Neoplasms: A Possible Mechanism Of Antitumor Action And Prospects For Use In Practice

This research discusses the potential antitumor effects of metformin, a common diabetes medication, noting its controversial influence on different malignant tumors and its uncertain mechanisms. Understanding these effects on tumors may aid in the development of new cancer treatments.

This study found that an 8-week stress management program significantly reduced perceived stress and improved glycemic control in patients with type 2 diabetes.

In this narrative review, researchers synthesized current evidence on topical metformin's potential benefits for various skin conditions, citing primarily preclinical studies that highlight its anti-inflammatory, antioxidant, and regenerative properties, although clinical translation requires further rigorous trials.

This scoping review revealed that topical metformin shows potential in dermatology, displaying anti-inflammatory, antioxidant, anti-photoaging, wound-healing, and antitumor properties, while also being effective for conditions like melasma and acne vulgaris; further clinical trials are needed to confirm its safety and efficacy for long-term human use.

This study suggests that metformin might serve as a diagnostic and therapeutic option to distinguish insulin resistance-related ovarian testosterone excess from a testosterone-secreting tumor in women with virilization.