Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that keratin expression patterns vary within nail unit structures, with the nail matrix uniquely expressing the acidic hair-type keratin Ha1.

This study identified various cell types in the canine claw, showing complex mechanisms of cellular differentiation similar to mammalian hair and human nails.

This study observed that the keratinization pattern of trichilemmal cysts in two Japanese women may originate from the proliferation of the outer root sheath in the follicular isthmus of anagen hairs.

This review examines the differentiation potential of epithelial cells from various sources in hair follicle formation, concluding that complex interactions are required for hair-specific characteristics, which were achieved in vivo but not in vitro.

This study explored the structure and keratin composition of marsupial hairs, finding similarities in keratin localization to hairs in placental mammals, and highlighting potential roles of trichohyalin and transglutaminase during hair development and shedding.

This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.

This study investigated the immunohistochemical characteristics of keratin proteins in epidermal appendages, finding variable staining patterns in different skin structures and tumor cells, which suggests differences in keratinization.

This study found that the SVpgC2a keratinocyte cell line, used as a model for dysplastic epithelium, showed increased apoptosis, proliferation, and aberrant keratin expression compared to normal keratinocytes from buccal mucosa.

This study reports that the fatty acid composition in cell membranes of stratified squamous epithelium varies with keratinization patterns, showing a partial essential fatty acid-deficient state in cultured keratinocytes.

This study found that trichoblastomas and nodular basal cell carcinomas have similar cytokeratin expression patterns, indicating differentiation towards the outer root sheath epithelium.

This study found that "early" transit amplifying cells, marked by CD271, are the first keratinocyte stem cell progenitors with distinct features, playing a significant role in early epidermal differentiation and regeneration.

This study identified and sequenced several keratin cDNA clones showing distinct expression patterns in mouse epithelia, with in situ hybridization highlighting differences in keratin distribution between normal and hyperproliferative tissues.

In this histopathology study of nevus sebaceus, researchers observed distinct epidermal, sebaceous, follicular, and apocrine changes, including sebaceous hyperplasia and basaloid adnexal proliferation, which help differentiate it from similar conditions like basal cell carcinoma and trichoblastoma.

In this study, hyperplastic layers of scabietic sheep skin showed expansive keratin labeling, indicating altered keratin expression compared to healthy skin.

This case report describes a unique instance of an otherwise healthy infant with phylloid terminal hair nevus, a form of hypomelanosis without extracutaneous abnormalities.

In this study, researchers observed that keratoacanthoma exhibits dynamic follicular differentiation throughout its stages, with changes in specific keratin expressions, and regressed lesions showing epidermal rather than follicular characteristics.

This study provides evidence for K1 and K10 derivatives' presence in the inner root sheath and hair cuticle, suggesting that these hair follicle parts may follow familiar keratinization principles.

This study found that quiescence in hair follicle stem cells acts as a tumor suppression mechanism for cutaneous squamous cell carcinoma, with Pten activity necessary to maintain this state.

This study found that K15 is variably expressed in sheep and mouse hair follicles, with specific patterns suggesting a role in the early stages of keratinocyte differentiation.

This case report discusses a 69-year-old woman with alopecia areata who presented with a growing lesion on her hand, raising diagnostic considerations during her appointment for scalp steroid injections.

Keratins change and are modified differently in skin layers and body parts.

This study found that while malignant pilomatricomas maintain some keratin expression patterns seen in benign counterparts, they notably express additional epithelial keratins, potentially influencing tumor calcification.

There are no new clinical results reported in this discussion of pityriasis rubra pilaris diagnosis and treatment, which notes frequent treatment failures and highlights reliance on clinical and histopathological findings.

The researchers reported that basal cell carcinoma tumor cells strongly express keratins typical of basal keratinocytes and some hair follicle components but lack differentiation markers, suggesting a follicular or pluripotent stem cell origin.

This study identified Sciellin, a new protein precursor to the cornified envelope in keratinocytes, with unique solubility properties hinting at its potential role in envelope assembly.