The Changes in the Expression Levels of Follicular Markers in Keratoacanthoma Depend on the Stage: Keratoacanthoma Is a Follicular Neoplasm Exhibiting Infundibular/Isthmic Differentiation Without Expression of CK15

    February 2014 in “ Journal of Cutaneous Pathology ”
    Noriyuki Misago, Toshihiro Takai, Shuji Toda, Yutaka NARISAWA
    Studysummary In this study, researchers observed that keratoacanthoma exhibits dynamic follicular differentiation throughout its stages, with changes in specific keratin expressions, and regressed lesions showing epidermal rather than follicular characteristics.
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    Research cited in this study 8

    1. Keratoacanthoma and Other Types of Squamous Cell Carcinoma with Crateriform Architecture: Classification and Identification The Journal of Dermatology · 2013
    2. Stem Cells and Alopecia: A Review of Pathogenesis British Journal of Dermatology · 2012
    3. Immunohistochemical Study of Calretinin in Normal Skin and Cutaneous Adnexal Proliferations American Journal of Dermatopathology · 2012
    4. Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    5. The Calcium-Binding Protein Calretinin Is a Marker of the Companion Cell Layer of the Human Hair Follicle British Journal of Dermatology · 2005
    6. Expression of the Hair Stem Cell-Specific Keratin 15 in Pilar Tumors of the Skin PubMed · 1999
    7. Cytokeratin 15 Expression in Trichoepitheliomas and a Subset of Basal Cell Carcinomas Suggests They Originate from Hair Follicle Stem Cells Journal of Cutaneous Pathology · 1999
    8. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999

    Related research 7

    1. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    2. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    3. Keratins of the Human Hair Follicle International review of cytology · 2005
    4. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    5. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003
    6. Formation and Structure of Human Hair Birkhäuser Basel eBooks · 1995
    7. Immunohistochemical Expression of Keratin Proteins in Keratoacanthomas of the Skin Oncology Reports · 1994