Human Stratified Squamous Epithelia Differ in Cellular Fatty Acid Composition

September 2000 in “ Journal of Dermatological Science ”

Hiroto TERASHI, Kenji Izumi, Lenore M Rhodes, Cynthia L. Marcelo

hair follicles essential fatty acid EFA linoleic acid phospholipids keratinocytes stratified squamous epithelium basal cells suprabasal layers

TLDR Fatty acid composition in human skin, mouth, and hair cells varies with keratinization, and cultured cells show essential fatty acid deficiency.

The study analyzed the fatty acid composition of phospholipids in basal cells from human skin epidermis, oral mucosa, and hair follicles, both in vivo and in vitro. It found that hair follicles exhibited a partial essential fatty acid (EFA)-deficient state in vivo. No significant differences were observed between the skin epidermis and oral mucosa in the basal layers, but the skin epidermis had a higher percentage of linoleic acid in the suprabasal layers compared to the oral mucosa. The study concluded that the fatty acid composition in cell membranes of stratified squamous epithelium varied with their keratinization pattern, and all three types of cultured keratinocytes showed an EFA-deficient pattern in membrane phospholipids.

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