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This study found that a novel saw palmetto supercritical CO2 extract effectively inhibits 5α-reductase type II in vitro, suggesting its potential for promoting prostate health in benign prostatic hyperplasia.

This study found that prenatal exposure to finasteride in rats disrupted male reproductive development, causing physical alterations such as delayed preputial separation and increased nipple retention.

Finasteride may improve sperm count in subfertile men with low sperm count.

In this review, the authors found no evidence of harmful pregnancy outcomes from exposure to finasteride, and report that handling the medication poses negligible risk to a fetus.

This study found that finasteride, which alters plant brassinosteroid metabolism, significantly reduced sporulation of the downy mildew pathogen in grapevines, unlike azole fungicide treatments.

This study found that resveratrol significantly alleviated testicular damage in male rats caused by finasteride, which otherwise led to decreased testosterone levels and various histopathological alterations in the testes.

In this chemical investigation, cyclospongiaquinone 1 from the sponge Verongula cf. rigida showed strong steroid 5α-reductase inhibitory activity, comparable to that of finasteride.

This study validated an HPLC analytical method for evaluating fenasteride in commercial products, finding it to be sensitive, selective, and within acceptance criteria for specificity, precision, and stability, making it suitable for quality control testing.

This study found that Origanum vulgare extract improved testicular structure and function in mice against finasteride-induced damage by enhancing antioxidant defense and modulating gene expression related to apoptosis.

The researchers reported that both finasteride and PM-9 competitively inhibit the 5 alpha-reductase enzyme in P. crustosum broth.

This review discusses the antimicrobial and protective effects of hesperidin and hesperetin against various toxicities, with potential mechanisms explored, but it reports no new research findings.

This study found that finasteride treatment in male rats may lead to changes in connexin 43 expression in the testes of their offspring, potentially affecting spermatogenesis.

This study found that both finasteride and a new steroidal compound, PM-9, competitively inhibit the 5α-reductase enzyme in Penicillium crustosum broth.

Finasteride may be a promising treatment for recurrent priapism in sickle cell anemia.

This study found that finasteride administration in hamsters led to significant spermatogenesis reduction and seminiferous tubule atrophy compared to the control group.

In this study, researchers developed a precise and rapid method for simultaneously analyzing minoxidil and finasteride in local therapeutic formulations, ensuring that the excipients did not interfere, making it suitable for routine quality control.

The researchers reported that both estrogen receptors ERα and ERβ are expressed in human testis, and identified two novel genes, Aven and Regucalcin, linked to estrogen and androgen regulation, which may be crucial for spermatogenesis.

This study found that prenatal exposure to finasteride in pregnant rats significantly disrupted male reproductive development, confirming its use as a positive control for androgen-related reproductive effects.

This study found that PK11195 treatment weakened exploratory behavior in two strains of mice, while finasteride and indomethacin decreased exploration in laboratory rodents regardless of species.

This study developed a synchronized fluorescence spectroscopic approach to quantify finasteride and tadalafil in various forms, achieving high accuracy with %recoveries of about 99.62% and 100.19% respectively, and demonstrated superior environmental friendliness compared to previous methods.

This study used an in silico/in vitro approach to identify potential inhibitors of the enzyme SRD5A2, finding that the androgen receptor modulator MK-0773 is a moderate inhibitor, although it does not act as a covalent inhibitor like finasteride.

This study found that forming solid dispersions and inclusion complexes of finasteride significantly increased its solubility compared to its pure form.

This study developed a rapid and efficient in vitro method using high-performance liquid chromatography to screen for steroid 5 alpha-reductase inhibitors, determining inhibition constants for Finasteride and Epristeride.

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

This study found that finasteride significantly reduced serum dihydrotestosterone levels, confirming its efficacy as a 5a-reductase inhibitor, while Permixon showed no effect in healthy male volunteers.