Neurosteroidogenesis and Exploratory Responses in Rodents
January 2014
in “
PubMed
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that PK11195 treatment weakened exploratory behavior in two strains of mice, while finasteride and indomethacin decreased exploration in laboratory rodents regardless of species.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The study investigated the effects of various substances on the exploratory behavior of male BALB/c mice, C57BL/6 mice, and Wistar rats using an open-field test. The substances tested included PK11195, indomethacin, finasteride, and pregnenolone. PK11195 was found to weaken exploratory behavior in mice, while both finasteride and indomethacin reduced exploratory responses across all rodent species and stress response phenotypes. Pregnenolone had an activating effect in the open-field test but also enhanced the inhibitory effect of finasteride in BALB/c mice.
