114 citations
,
February 2012 in “International Journal of Dermatology” This review examines the dermatologic effects of tobacco use and nicotine, noting potential benefits and drawbacks for various skin conditions, but reports no new clinical results.
105 citations
,
April 2014 in “Trends in Pharmacological Sciences” This review discusses the therapeutic potential of Smoothened modulators for cancer treatment and explores their pharmacological implications, but reports no new clinical findings.
91 citations
,
November 2007 in “Archives of Dermatology” In this study, smoking status and intensity were significantly associated with moderate or severe androgenetic alopecia among Asian men, after accounting for age and family history.
66 citations
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March 2018 in “British journal of dermatology/British journal of dermatology, Supplement” This article reviews the role of perifollicular regulatory T cells in maintaining hair follicle integrity in the context of hidradenitis suppurativa and calls attention to inflammatory mechanisms without reporting new clinical results.
63 citations
,
May 2011 in “Clinical cancer research” In this study, topical CUR61414 was effective in inhibiting basal cell carcinomas in mice, but no clinical activity was observed in human trials.
50 citations
,
November 2010 in “Tissue Engineering Part A” This study found that combining hair follicle-derived smooth muscle cells with a natural biomaterial created vascular constructs with mechanical and functional properties similar to native arteries, suggesting potential for arterial implantation.
46 citations
,
December 2014 in “Journal of The American Academy of Dermatology” This study found that smoking, obesity, and family history are significant risk factors for premature hair graying in young men.
34 citations
,
September 2013 in “Urology” Long-term use of a certain medication can worsen erectile function in aged rats by damaging penile muscle cells.
21 citations
,
May 2017 in “International Journal of Dermatology” This study found that among Caucasian individuals with androgenetic alopecia, being overweight and smoking were associated with greater severity of the condition.
19 citations
,
January 2015 in “Current problems in dermatology” This review discusses environmental factors like UV radiation and smoking that affect hair health and highlights the potential role of nutrition, but it reports no new results.
19 citations
,
September 2013 in “Molecular Medicine Reports” In this study, researchers developed a method to efficiently derive contractile smooth muscle cells from human hair follicle stem cells using TGF-β1 and PDGF-BB, which may advance vascular tissue engineering.
16 citations
,
March 2015 in “Clinical Cancer Research” This review discusses the mechanism and side effects of smoothened inhibitors for advanced basal cell carcinoma, reporting no new clinical results and highlighting current management strategies for these adverse events.
8 citations
,
May 2019 in “Journal of dermatological treatment” This study found that vismodegib was effective in treating basal cell carcinoma, achieving complete remission in some patients; however, significant side effects often required careful management to prevent therapy suspension, which can lead to resistance.
7 citations
,
June 2010 in “Bioorganic & medicinal chemistry letters” This study found that aminomethylpyrazole compound 10l inhibited hair growth in a mouse model and showed a low risk for photo-irritation, though it was slightly less effective than eflornithine.
4 citations
,
January 2015 in “Dermatology Online Journal” This study highlights that smoker's mustache, a tobacco-related hair discoloration on the upper lip, is asymptomatic, generally unnoticed, and may resolve if smoking is discontinued, though patients often continue smoking.
3 citations
,
October 2021 in “Cureus” This review discusses yellow hair discoloration associated with smoking and systemic conditions, proposing smoking cessation or hair removal as management options, but provides no new clinical results.
2 citations
,
June 2022 in “International Journal of Molecular Sciences” This study found variable outcomes in hair loss treatment with autologous cell-based therapy using DSC cells, with certain gene markers showing inconsistent correlations with treatment efficacy.
1 citations
,
August 2012 in “Journal of Emerging Trends in Engineering and Applied Sciences” This study found that smoking may lead to earlier onset of androgenetic alopecia in Nigerian subjects, potentially mediated by alterations in serum trace elements.
The study reported that vismodegib showed significant effectiveness in treating basal cell carcinoma, particularly in patients with Gorlin-Goltz syndrome or locally advanced BCC, but also highlighted substantial side effects, requiring careful management to prevent treatment resistance and maintain remission.
June 2010 in “Melanoma research” This study found that LDE225, a novel Smo antagonist, shows potential as a topical treatment for basal cell carcinoma due to its high affinity binding and effective inhibition of tumor growth in preclinical models.
In preclinical studies, topical CUR61414 reduced Hh signaling and shrank BCCs in mice, but this study found no clinical efficacy in human superficial or nodular BCCs.
February 2026 in “South African Journal of Botany” In this study, rice straw-derived smoke water enhanced root growth in rice plants by increasing root meristem size and cell proliferation, reducing superoxide accumulation under phosphorus deficiency, and altering internal phosphorus partitioning, although it suppressed root hair elongation, which affected phosphate uptake.
July 2025 in “Pakistan Journal of Medicine and Dentistry” This study found a significant association between smoking and both the presence and severity of androgenetic alopecia among adult males, suggesting that smoking may be a modifiable risk factor for this common form of hair loss.
October 2024 in “Comprehensive Health and Biomedical Studies” In this study, conducted at the Jordan Clinic in Tehran, smokers and alcohol users who underwent hair transplantation had significantly worse outcomes, such as lower hair density and growth, compared to non-smokers and non-drinkers, highlighting the negative impact of these lifestyle factors on treatment efficacy.
September 2024 in “Dermatologica Sinica” This article describes a 10-month-old female with congenital smooth muscle hamartoma, highlighting the importance of differential diagnosis in congenital skin lesions due to potential malignancy risks.
September 2024 in “Journal of the American Academy of Dermatology” This meta-analysis found that smoking is significantly associated with increased odds of developing and progressing androgenetic alopecia, with higher risks observed in men smoking at least 10 cigarettes daily.
April 2024 in “American Journal of Case Reports” This case study reported that endotracheal hair growth following tracheal restructuring with an autograft was associated with cigarette smoking, and was ultimately stopped by argon plasma laser-coagulation and smoking cessation.
January 2024 in “Journal of Cosmetic Dermatology” This study found that men who smoke are more likely to develop androgenetic alopecia and experience disease progression compared to non-smokers.
June 2023 in “Journal for international medical graduates” This study observed a significant association between smoking and an increased risk of hair loss, including male pattern baldness, and highlights the need for interventions at individual, community, and national levels to address smoking-related hair loss.
October 2022 in “Boletín médico del Hospital infantil de México/Boletín médico del Hospital Infantil de México” This case report describes an 18-year-old male with a rare acquired smooth muscle hamartoma on his face, characterized by hyperpigmented plaques and increased hair growth, suggesting a histological overlap with folliculosebaceous cystic hamartoma.