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    Glossary Small Molecule Inhibitor

    blocks specific proteins or enzymes within cells

    A Small Molecule Inhibitor (SMI) is a type of drug that can enter cells easily due to its low molecular weight and can interfere with specific proteins or enzymes to block their activity. These inhibitors are often used in treatments for various diseases, including cancer and autoimmune disorders, by targeting and disrupting specific pathways that contribute to disease progression.

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    Research 30 of 1000+

    1. 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment Journal of Investigative Dermatology · 2017
    2. Small Molecule Inhibitors and Inflammatory Skin Diseases Suez Canal University Medical Journal · 2018
    3. Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review Dermatology and Therapy · 2026
    4. A systematic review of tumor necrosis factor-α blockers, anti-interleukins, and small molecule inhibitors for dissecting cellulitis of the scalp treatment Orphanet Journal of Rare Diseases · 2025
    5. A Small Molecule Inhibitor Partitions Two Distinct Pathways for Trafficking of Tonoplast Intrinsic Proteins in Arabidopsis PloS one · 2012 · 35 citations
    6. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
    7. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    8. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
    9. Data from Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened 2023
    10. Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review Indian Dermatology Online Journal · 2024 · 1 citations
    11. A machine learning and network framework to discover new indications for small molecules bioRxiv (Cold Spring Harbor Laboratory) · 2019
    12. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    13. Biologics and small molecules for patients with concomitant alopecia areata and vitiligo: A review International Journal of Dermatology · 2024
    14. High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth Communications Biology · 2026
    15. Stimulation of Hair Growth by Small Molecules that Activate Autophagy Cell reports · 2019 · 88 citations
    16. Modulating Aging and Aging-related Symptoms Using Endogenous Small Molecules 2019
    17. A machine learning and network framework to discover new indications for small molecules PLOS Computational Biology · 2020 · 8 citations
    18. 712 A small molecule modulator of the wnt pathway (SM04554) as a potential topical treatment for androgenetic alopecia (AGA) Journal of Investigative Dermatology · 2017 · 1 citations
    19. The antiviral activity of a small molecule drug targeting the NSP1-ribosome complex against Omicron, especially in elderly patients Frontiers in Cellular and Infection Microbiology · 2023 · 6 citations
    20. DEVELOPING NEW DUAL-ACTION ANTIVIRAL/ANTI-INFLAMMATORY SMALL MOLECULES FOR COVID-19 TREATMENT USING IN SILICO AND IN-VITRO APPROACHES 2024
    21. Targeting the Wnt pathways for therapies Molecular and cellular therapies · 2014 · 112 citations
    22. The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine Journal of Cellular Physiology · 2017 · 89 citations
    23. Editorial: Crosstalk: skin cells and immune cells in inflammatory skin diseases Frontiers in Immunology · 2024 · 3 citations
    24. Recent Advances in Drug Development for Hair Loss International Journal of Molecular Sciences · 2025
    25. Editorial: Targeted immunological therapies in dermatology Frontiers in Medicine · 2024
    26. 1359 Hair growth is induced by blockade of macrophage-derived oncostatin M and downstream JAK-STAT5 signaling in hair follicle stem cells Journal of Investigative Dermatology · 2018
    27. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    28. Editorial: Exploring innovative therapies for rare inflammatory skin diseases Frontiers in Medicine · 2026
    29. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    30. Mechanisms of autophagy and their implications in dermatological disorders Frontiers in Immunology · 2024 · 6 citations