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This study suggests that human skin locally synthesizes active sex steroid hormones, impacting inflammation, cell behavior, and wound healing, with potential implications for therapies in aging and impaired wound recovery.

This review discusses the distinct roles and surprising developmental flexibility of multiple somatic stem cell types in tissue maintenance and repair, reporting no new results but highlighting emerging questions about their regulation and origins.

This research found that Foxc1 is critical for maintaining quiescence in activated hair follicle stem cells and that the cancer cell-of-origin influences tumor heterogeneity in mouse skin squamous cell carcinoma.

Retinoic acids temporarily change skin stem cells to a slower cycle and more differentiated state.

This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.

This study found that, in mouse tail epidermis, stem cells rapidly activate and regenerate new progenitors to repair wounds, with mechanisms affecting their proliferation, differentiation, and migration.

This study proposes a model suggesting that the ratio of keratin 15 to keratin 14 in epidermal keratinocytes promotes a progenitor state and opposes differentiation, based on insights from both cell culture and transgenic mouse models.

This review highlights how peripheral nerves play key roles in skin wound healing by modulating immune responses, regulating stem cell functions, and promoting vascularization, suggesting potential avenues for therapeutic strategies targeting neuroregulation.

This study found that fibroblast behavior switching between proliferation and ECM deposition is vital for dermal architecture, where cell migration is primarily important for tissue repair during wound healing.

This review discusses the dynamic, niche-driven regulation of stem cell states in tissue homeostasis and regeneration, focusing on epithelial stem cells in the mammalian skin, intestine, and lung, without providing new experimental results.

In this study, researchers using live mice observed that oncogenic Kras mutation disrupts hair follicle architecture by sustaining ERK signal activation, which affects stem cell behavior and tissue integrity.

This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.

This study demonstrates that keratinocyte cell lines derived from cultured hair follicles can fully differentiate in organotypic skin models, offering a minimally invasive alternative to obtaining keratinocytes for research.

This review explores the regenerative potential of hair follicles and their role in complete skin regeneration, emphasizing the influence of mechanical factors and niche signaling pathways on hair growth and loss.

This study highlights how the COVID-19 pandemic has exacerbated stress-related dermatological issues like acne and hair loss by affecting skin and hair cycles through stress hormones, emphasizing the need for comprehensive psychoneuroendocrine-informed approaches to diagnosis and treatment.

This review discusses recent findings on the plasticity and regulation of epithelial stem cells and reports no new experimental results.

This review summarizes the roles of matricellular proteins in skin stem cell niches, highlighting their contribution to stem cell fate, self-renewal, and potential implications for wound healing and aging.

This chapter reviews the properties and applications of epidermal stem cells in skin tissue engineering and transplantation but reports no new experimental results.

This study found that the circadian clock regulates the activation state of murine epidermal stem cells, affecting tissue homeostasis and susceptibility to tumorigenesis when disrupted.

Vitamin D affects skin and hair by influencing cell behavior and melanin production.

This review explores how epidermal stem cells contribute to the development and maintenance of various skin structures, and highlights specific markers and proteins associated with these cells, but reports no new clinical results.

This article explores the potential of chitin nanofibrils as a bioactive polymer for skin applications by examining their hydrophilic properties and effects on cell behavior, but presents no new experimental results.

This article provides an overview of the biological process of skin wound healing, detailing the roles of keratinocytes, dermal cells, and trichogenesis without presenting new experimental results.

In this study, researchers developed a custom-designed 3D-printed microscope stage insert for inverted confocal microscopes, enhancing the accessibility of long-term intravital imaging of live cell dynamics in live transgenic mice, particularly in the skin.

This study identified the transcription factor Elf5 as a novel regulator of keratinocyte proliferation and differentiation in skin, with expression elevated in stem/progenitor cell populations, suggesting its potential role in determining cell fate during skin and hair development.

SPRY1 deficiency in skin cells causes stem cells to move to the skin surface, leading to increased pigmentation.

This study found that scalp basal cell carcinomas do not appear to behave more aggressively than other types, despite suggestions in the literature.

The researchers reported that hair follicle germinative epidermal cells can form complex structures when associating with papilla cells in culture, unlike other types of epidermal cells.

This case report describes a Canadian Husky dog with sertolioma that exhibited dermatological symptoms and aggressive behavior, both of which improved significantly after surgery.

In a transgenic mouse model, this study found that overexpression of keratin 16 in skin keratinocytes led to hyperkeratosis and increased EGF receptor signaling, altering skin cell behavior and structure.