Local Synthesis and Effect of Sex Steroids in Human Skin and the Hair Follicle and Hormonal Effects on the Wound Healing Response

    January 2011 in “ Padua Research Archive (University of Padua) ”
    Elena Pomari
    Studysummary This study suggests that human skin locally synthesizes active sex steroid hormones, impacting inflammation, cell behavior, and wound healing, with potential implications for therapies in aging and impaired wound recovery.
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    Research cited in this study 36

    1. Female Pattern Hair Loss: Beyond an Androgenic Aetiology? British Journal of Dermatology · 2010
    2. 17β-Estradiol Inhibits Wound Healing in Male Mice via Estrogen Receptor-α American Journal Of Pathology · 2010
    3. Female Pattern Hair Loss in Complete Androgen Insensitivity Syndrome British Journal of Dermatology · 2010
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    6. Androgen Dependence of Hirsutism, Acne, and Alopecia in Women Medicine · 2009
    7. Androgens and Hair Growth Dermatologic Therapy · 2008
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    9. Different Patterns of 5α-Reductase Expression, Cellular Distribution, and Testosterone Metabolism in Human Follicular Dermal Papilla Cells Biochemical and Biophysical Research Communications · 2008
    10. Frontiers in the Neuroendocrine Controls of Hair Growth Journal of Investigative Dermatology Symposium Proceedings · 2007
    11. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
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    22. Human Skin Is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1) Journal of Investigative Dermatology · 2003
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    24. Regulatory Roles of Androgens in Cutaneous Wound Healing Thrombosis and Haemostasis · 2003
    25. Steroidogenic Isoenzymes in Human Hair and Their Potential Role in Androgenetic Alopecia Dermatology · 2003
    26. Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    27. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    28. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001
    29. 5α-Reductase Activity in the Prostate Urology · 2001
    30. Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2001
    31. Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
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    Related research 2

    1. Sex Steroid Synthesis in Human Skin In Situ: The Roles of Aromatase and Steroidogenic Acute Regulatory Protein in the Homeostasis of Human Skin Molecular and Cellular Endocrinology · 2012
    2. Skeletal Site-Dependent Expression of the Androgen Receptor in Human Osteoblastic Cell Populations Calcified Tissue International · 1997