Vitamin D: Role in Skin and Hair

January 2005 in “ Elsevier eBooks ”

Daniel D Bikle, Daniel D Bikle

vitamin D melanin UV-B vitamin D3 keratinocytes 25(OH)D 1,25(OH)2D keratinocyte differentiation melanocyte apoptosis melanin production

TLDR Vitamin D affects skin and hair by influencing cell behavior and melanin production.

The document discussed the role of vitamin D in skin and hair, highlighting that melanin skin pigmentation significantly reduced UV-B-mediated synthesis of vitamin D3, similar to the effect of sunscreen. It noted that keratinocytes could hydroxylate 25(OH)D to produce 1,25(OH)2D, which might regulate keratinocyte differentiation, melanocyte apoptosis, and melanin production. This regulation could serve as a feedback mechanism for controlling the cutaneous synthesis of vitamin D3.

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