Vitamin D: Role in Skin and Hair

January 2005 in “ Elsevier eBooks ”

Daniel D Bikle, Daniel D Bikle

vitamin D melanin UV-B vitamin D3 keratinocytes 25(OH)D 1,25(OH)2D keratinocyte differentiation melanocyte apoptosis melanin production

TLDR Vitamin D affects skin and hair by influencing cell behavior and melanin production.

The document discussed the role of vitamin D in skin and hair, highlighting that melanin skin pigmentation significantly reduced UV-B-mediated synthesis of vitamin D3, similar to the effect of sunscreen. It noted that keratinocytes could hydroxylate 25(OH)D to produce 1,25(OH)2D, which might regulate keratinocyte differentiation, melanocyte apoptosis, and melanin production. This regulation could serve as a feedback mechanism for controlling the cutaneous synthesis of vitamin D3.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

140 citations , April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme 25 Hydroxyvitamin D 1 α-Hydroxylase is essential for healthy skin and recovery after skin damage.

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues Alopecia in Vitamin D Receptor Null Mice

research Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues Alopecia in Vitamin D Receptor Null Mice

57 citations , April 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D receptor is crucial for starting hair growth after birth.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

180 citations , January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is crucial for normal skin and hair growth.

research Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia

115 citations , December 2001 in “Endocrinology”

Expressing the human vitamin D receptor in skin cells prevents hair loss in certain mice.

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

139 citations , September 2001 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the Vitamin D receptor gene can cause hair loss similar to mutations in the Hairless gene.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

519 citations , October 1998 in “Endocrinology”

Diet can prevent bone issues but not hair loss in mice lacking vitamin D receptors.

research Calcitriol-Resistant Rickets With Alopecia

55 citations , May 1985 in “Archives of Dermatology”

Calcitriol-resistant rickets is an inherited disorder that affects hair growth and causes hair loss.

Vitamin D: Role in Skin and Hair

Research cited in this study

research 25 Hydroxyvitamin D 1 Alpha-Hydroxylase Is Required for Optimal Epidermal Differentiation and Permeability Barrier Homeostasis

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

research Targeted Expression of Human Vitamin D Receptor in the Skin Promotes the Initiation of the Postnatal Hair Follicle Cycle and Rescues Alopecia in Vitamin D Receptor Null Mice

research Molecular Mechanisms Regulating Hair Follicle Development

research Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth

research Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia

research Atrichia Caused by Mutations in the Vitamin D Receptor Gene Is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

research Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice

research Extrarenal Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase

research Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis

research Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice

research The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation

research Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice

research Alopecia Universalis Associated With a Mutation in the Human Hairless Gene

research Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity

research Cellular Localization of Retinoic Acid Receptor-Gamma Expression in Normal and Neoplastic Skin

research Analysis of the Relation Between Alopecia and Resistance to 1,25-Dihydroxyvitamin D

research Calcitriol-Resistant Rickets With Alopecia