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Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

Testosterone is vital for male health, and its deficiency is linked to aging and common health issues.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

Activin B helps start and grow hair follicles in mice.

Hormonal imbalances during menopause may significantly contribute to Frontal Fibrosing Alopecia.

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

Recent hair loss research shows some progress, especially in understanding male pattern baldness, but effective treatments for many types of hair loss are still lacking.

Different enzymes are active in different parts of developing mouse organs.

BRL 7660, once studied for male contraception, showed promise as an acne treatment but was not developed further due to competing drugs.

Mouse genital development depends on male or female hormones for specific features.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Thyroid hormones and androgens affect gene expression in frog reproductive organs differently between males and females.

Finasteride has different absorption and metabolism in male and female rats, with higher concentrations in certain organs and mostly excreted through feces.

Women may need different blood pressure guidelines than men for heart disease prevention.

Low selenium intake may delay puberty in boys but not in girls.

Female donor to male recipient sex mismatch and positive ACA-IgG are key risk factors for vitiligo and alopecia areata in chronic GvHD patients.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.

Changes in gut bacteria can contribute to the development of Polycystic Ovary Syndrome (PCOS), affecting metabolism, immunity, and causing inflammation. Treatments may involve adjusting these factors.

The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Lizards can regrow their tail scales with the same structure, distribution, and gender-specific features as the original ones, and this unique ability is not seen in adult mammals.

The conclusion is that skin and hair patterns are formed by a mix of cell activities, molecular signals, and environmental factors.