Risk Factors and Characterization of Vitiligo and Alopecia Areata in Patients With Chronic Graft-Versus-Host Disease

    September 2014 in “ JAMA dermatology ”
    Ruochen Zuo, Haley B. Naik, Seth M. Steinberg, Kristin Baird, Sandra A. Mitchell, Zoya Kuzmina, Steven Z. Pavletić, Edward W. Cowen
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    TLDR Female donor to male recipient sex mismatch and positive ACA-IgG are key risk factors for vitiligo and alopecia areata in chronic GvHD patients.
    This study investigated the risk factors and characteristics of vitiligo and alopecia areata (AA) in 282 patients with chronic graft-vs-host disease (GvHD). It found that 5.3% of patients exhibited vitiligo and/or AA. Key risk factors identified included female donor to male recipient sex mismatch, positive anticardiolipin (ACA) IgG, positive antiparietal antibody, elevated CD19 level, and normal or elevated IgG level. Multivariable analysis confirmed the significance of female donor to male recipient sex mismatch and positive ACA-IgG. The study concluded that these factors are significantly associated with the development of vitiligo and/or AA in chronic GvHD patients, suggesting the need for further research to understand the underlying mechanisms.
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