Risk Factors and Characterization of Vitiligo and Alopecia Areata in Patients With Chronic Graft-Versus-Host Disease

    September 2014 in “ JAMA dermatology ”
    Ruochen Zuo, Haley B. Naik, Seth M. Steinberg, Kristin Baird, Sandra A. Mitchell, Zoya Kuzmina, Steven Z. Pavletić, Edward W. Cowen
    Image of study
    TLDR Female donor to male recipient sex mismatch and positive ACA-IgG are key risk factors for vitiligo and alopecia areata in chronic GvHD patients.
    This study investigated the risk factors and characteristics of vitiligo and alopecia areata (AA) in 282 patients with chronic graft-vs-host disease (GvHD). It found that 5.3% of patients exhibited vitiligo and/or AA. Key risk factors identified included female donor to male recipient sex mismatch, positive anticardiolipin (ACA) IgG, positive antiparietal antibody, elevated CD19 level, and normal or elevated IgG level. Multivariable analysis confirmed the significance of female donor to male recipient sex mismatch and positive ACA-IgG. The study concluded that these factors are significantly associated with the development of vitiligo and/or AA in chronic GvHD patients, suggesting the need for further research to understand the underlying mechanisms.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 7 results

      community 1 Month Topical Minoxidil Only

      in Progress Pictures  72 upvotes 1 year ago
      The conclusion of the conversation is that the user plans to use topical minoxidil, ketoconazole shampoo, and a derma stamp for hair loss treatment. They also plan to start using finasteride in the next 2 months. Other users suggest using finasteride and a hair transplant for better results. The user appreciates the feedback and will continue posting progress.

      community Quit vaping/smoking = 80% less loss

      in Research/Science  235 upvotes 8 months ago
      Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

      community fin 0.5 mg everday 6 months update

      in Finasteride/Dutasteride  28 upvotes 1 year ago
      The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

      community One full year of treatment before and after

      in Progress Pictures  18 upvotes 4 months ago
      A user shared their one-year progress with hair loss treatment, using topical minoxidil, 2% keto shampoo, microneedling, and finasteride. They plan to start dutasteride and are considering switching to oral minoxidil.

      community Fighting Hair loss AND Grey Hair

      in Treatment  18 upvotes 2 years ago
      The user is treating hair loss with topical Minoxidil, Finasteride, RU58841, microneedling, and Ketoconazole. For grey hair, they use L-Cysteine, L-Methionine, and PABA, and have noticed some re-pigmentation.

    Related Research

    1 / 1 results