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This systematic review synthesizes evidence on the distribution of 5a-reductase isozymes and their implications for mental health, finding that inhibition of neurosteroidogenesis may contribute to anxiety, depression, and suicidality, with some patients experiencing persistent psychiatric effects from finasteride or dutasteride.

This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.

This study concluded that combining the Shumin treatment instrument with oral doxycycline provides better clinical outcomes for rosacea than combining red light therapy with doxycycline, while both regimens improved quality-of-life scores and reduced Demodex counts.

This abstract reviews 5α-reductase inhibitors and their side effects in patients with sexual dysfunction but reports no new findings.

This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.

This study found that antisense oligonucleotides can significantly reduce androgen receptor expression in cultured human sebocytes and may offer new therapeutic possibilities for androgen-associated skin diseases.

This study used an in silico/in vitro approach to identify potential inhibitors of the enzyme SRD5A2, finding that the androgen receptor modulator MK-0773 is a moderate inhibitor, although it does not act as a covalent inhibitor like finasteride.

This study found that cationic vesicles enhanced minoxidil skin retention and in vivo hair growth efficacy compared to other formulation types due to electrostatic interactions with the skin.

This study observed that patients using Erol(®) Energy shampoo and tonic reported improved symptoms of scalp irritation and rated product tolerance as good to excellent.

In this study, 13-cis-5S*,8S*-epidioxy-5,8-dihydroretinoic acid was found to be significantly more cytotoxic to cancer cell lines than other retinoic acid analogs evaluated.

This study identified novel compounds as selective inhibitors of the type 1 isoenzyme of 5α-reductase, displaying promising potential for treating DHT-dependent disorders such as acne and androgenic alopecia.

This study found that MK-386 selectively suppressed sebum DHT levels in a dose-dependent manner, suggesting potential use for treating acne.

This study discovered that the disposition of LY191704 enantiomers in rats and dogs is both stereoselective and species specific.

This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.

This study found that applying ivermectin 1% cream significantly improved both visible symptoms like erythema and invisible symptoms such as stinging, burning, and dryness in rosacea patients over a period of at least 16 weeks.

Deuruxolitinib improves anxiety and depression in severe alopecia areata patients.

This study found that Hydroxypinacolone Retinoate (HPR) may alleviate UV-induced skin photoaging by enhancing collagen synthesis, reducing degradation, and modulating inflammatory and oxidative responses in a dose-dependent manner.

In this case study, a 25-year-old female with premature hair graying achieved over 90% conversion of gray hair to black hair after 5 months of treatment with a topical peptide solution and hair supplements.

This review explores the potential of topical minoxidil as a treatment for erectile dysfunction, indicating that while a mild erectile response was observed, evidence remains insufficient for confirmation.

This source describes Protetox as a natural dietary supplement that aids in weight loss by detoxifying the body, utilizing a blend of plant-based ingredients and antioxidants, and claims users have reported significant weight loss without changing their diet or exercise routines.

This research review observed that topical hormone replacement therapy, particularly estradiol and estradiol-testosterone combinations, significantly increased Type I and III collagen synthesis in the skin of postmenopausal women, suggesting benefits against collagen loss-related skin aging effects such as reduced elasticity and increased dryness.

This study found that bupropion SR may improve symptoms in female trichotillomania patients who did not respond to SSRIs, with benefits maintained through a 16-month follow-up.

This study found that chemical peeling significantly improved men's self-esteem and quality of life, making it an effective low-commitment treatment option for various skin conditions.

This study found that the nonionic surfactant Brij 78 stabilized cationic minoxidil microparticles against aggregation, maintaining their substantivity in the presence of excess anionic surfactant.

In this study, researchers found that a propylene glycol-free and alcohol-reduced topical foam containing minoxidil and finasteride remained chemically, physically, and microbially stable for 180 days when stored properly at room temperature in light-resistant containers.

This study developed a new crystallization method using solid solution formation to purify finasteride by effectively removing contamination with dihydrofinasteride.

This review discusses various treatments for pityriasis rubra pilaris, including vitamin A, methotrexate, and systemic steroids, reporting historical anecdotal evidence without new clinical results.

This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.

This study generated a pharmacophoric model for both isoforms of steroidal 5α-reductase using 6-azasteroids, providing a structural framework for designing new inhibitors.