High-Performance Liquid Chromatographic Determination of the Enantiomers of the Benzoquinolinone LY 191704, a Human Type 1 5α-Reductase Inhibitor, in Plasma

    March 1997 in “ Journal of Chromatography B: Biomedical Sciences and Applications ”
    Nagy A. Farid, Nikola L. Coleman
    Image of study
    TLDR Researchers developed a method to measure different forms of a drug that could help treat prostate issues and hair loss, and found how these forms behave in animals.
    In 1997, researchers developed an HPLC method to determine the enantiomeric ratio of LY300502 and LY300503, enantiomers of LY191704, a selective inhibitor of the enzyme human type 1 5α-reductase, which is linked to prostate cancer, benign prostate hyperplasia, acne, and androgenic alopecia. The method used extraction from rat and dog plasma and achieved enantiomer recovery rates of 82% to 96% with accuracy ranging from 88% to 114%. The study revealed stereoselective and species-specific disposition of the enantiomers in rats and dogs, with one enantiomer experiencing greater first-pass metabolism in rats. This research aided in selecting the most promising compound for further development based on the in vivo behavior of the enantiomers.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 90 results

      community Hair Loss Drugs Ranked in Order of Efficacy

      in Research/Science  67 upvotes 11 months ago
      Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 9 months ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 2 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Massive study on finasteride side effects released

      in Finasteride/Dutasteride  83 upvotes 1 year ago
      The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

    Related Research

    1 / 1 results