Minoxidil Prevents MDMA-Induced Serotonin Depletions: Role of Mitochondrial ATP-Sensitive Potassium Channels, Akt, and ERK

February 2008 in “ Journal of Neurochemistry ”

Beatriz Goñi-Allo, Elena Puerta, María Marcos Ramos, Berta Lasheras, Joaquín Jordán, Norberto Aguirre

minoxidil mitochondrial ATP-sensitive potassium channels Akt phosphorylation ERK mitoKATP channel blocker 5-HD Rogaine

TLDR Minoxidil prevents serotonin loss from MDMA by affecting potassium channels and increasing Akt phosphorylation.

Minoxidil, a drug used to treat hair loss, has been found to prevent serotonin depletion caused by the drug MDMA in rats. The study found that the neuroprotective effects of minoxidil depend on the opening of mitochondrial ATP-sensitive potassium channels, rather than those located in the sarcolemma. The study also found that minoxidil up-regulates Akt phosphorylation in the striatum, and that the protective effects of minoxidil were completely abolished by the mitoKATP channel blocker 5-HD.

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Research cited in this study

3 / 3 results

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

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research Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

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Minoxidil protects heart and improves recovery.

research Management of Androgenetic Alopecia

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Treatments for common hair loss include minoxidil, finasteride, and hair transplantation.

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research Minoxidil Prevents MDMA-Induced Serotonin Depletions: Role of Mitochondrial ATP-Sensitive Potassium Channels, Akt, and ERK

22 citations, February 2008 in “Journal of Neurochemistry”

Minoxidil prevents serotonin loss from MDMA by affecting potassium channels and increasing Akt phosphorylation.

Minoxidil Prevents MDMA-Induced Serotonin Depletions: Role of Mitochondrial ATP-Sensitive Potassium Channels, Akt, and ERK

Research cited in this study

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

research Minoxidil Opens Mitochondrial KATP Channels and Confers Cardioprotection

research Management of Androgenetic Alopecia

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research Minoxidil Prevents MDMA-Induced Serotonin Depletions: Role of Mitochondrial ATP-Sensitive Potassium Channels, Akt, and ERK