MK-386, an Inhibitor of 5α-Reductase Type 1, Reduces Dihydrotestosterone Concentrations in Serum and Sebum Without Affecting Dihydrotestosterone Concentrations in Semen

    May 1997 in “ The Journal of Clinical Endocrinology & Metabolism ”
    Jules I. Schwartz, Wesley Tanaka, Daniel Z. Wang … Barry J. Gertz
    Studysummary This study found that MK-386 selectively suppressed sebum DHT levels in a dose-dependent manner, suggesting potential use for treating acne.
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    Research cited in this study 9

    1. Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men The Journal of Clinical Endocrinology and Metabolism · 1996
    2. Clinical Review 73: Medical Treatment of Androgen-Dependent Hirsutism ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 1995
    3. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    4. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992
    5. Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers The Journal of Clinical Endocrinology and Metabolism · 1990
    6. Correlation of Serum 3α-Androstanediol Glucuronide with Acne and Chest Hair Density in Men The Journal of Clinical Endocrinology & Metabolism · 1988
    7. 3 Alpha, 17 Beta-Androstanediol Glucuronide in Plasma: A Marker of Androgen Action in Idiopathic Hirsutism ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 1982
    8. Testosterone Metabolism in the Skin Archives of dermatology · 1975
    9. Testosterone Metabolism in the Skin: A Review of Its Function in Androgenetic Alopecia, Acne Vulgaris, and Idiopathic Hirsutism Including Recent Studies with Antiandrogens Archives of Dermatology · 1975

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    3. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    4. A Model for the Turnover of Dihydrotestosterone in the Presence of the Irreversible 5α-Reductase Inhibitors GI198745 and Finasteride Clinical Pharmacology & Therapeutics · 1998
    5. Effect of MK-386, a Novel Inhibitor of Type 1 5 Alpha-Reductase, Alone and in Combination with Finasteride, on Serum Dihydrotestosterone Concentrations in Men The Journal of Clinical Endocrinology and Metabolism · 1996
    6. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994