Novel Effects of Ivermectin in Rosacea: Reduction of Erythema, Flushing, Skin Texture, and Invisible Symptoms

A pilot study involving 25 Caucasian patients with moderate to severe rosacea found that ivermectin 1% cream significantly reduced both visible and invisible symptoms of the condition. The patients applied 1 g of the cream once a day for at least 16 weeks. The visible symptoms, such as erythema, were measured using clinician erythema assessment (CEA) and patient self-assessment (PSA), while invisible symptoms like stinging, burning, and dryness were evaluated through a questionnaire. The results showed significant reductions in both CEA and PSA (p<0.0001), as well as in invisible symptoms (stinging/burning, dryness: p<0.0001; itching: p<0.001). The findings were confirmed using the Scarletred® Vision tool, which also showed improvements in erythema (p<0.0001) and skin roughness (p<0.001). The study concluded that ivermectin 1% cream is effective in treating rosacea-associated symptoms and that Scarletred® Vision is a useful tool for objectively analyzing treatment success.