The authors discussed the potential benefits of Urtica dioica and Serenoa repens for hair health, but emphasized that more concrete evidence and standardized formulations are necessary for reliable therapeutic use.
November 2025 in “Journal of Cosmetic Dermatology” This study found that a proprietary saw palmetto (Serenoa repens) extract significantly increased hair growth and reduced hair shedding in men and women with self-perceived thinning hair over a 90-day period, compared to placebo, without reported adverse events.
July 2025 in “Nutrición clínica y dietética hospitalaria/Nutrición clínica, dietética hospitalaria” This study reviewed various supplements for treating androgenetic alopecia and found that Serenoa repens shows the strongest evidence for use as a single treatment, while ketoconazole may help as an adjunct. Other supplements like zinc, vitamin D, and biotina are not recommended unless deficiencies exist.
May 2025 in “Frontiers in Bioinformatics” This study used computational methods to identify six molecules, with jamogenin being particularly promising, that effectively bind to and inhibit the enzyme linked to male pattern hair loss, suggesting these compounds could be explored further for hair growth potential.
May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this study, researchers used computational methods to identify six phytochemicals from nettle, saw palmetto, and fenugreek as effective binders to 5-alpha reductase, with Jamogenin showing enhanced stability when encapsulated in lipid nanoparticles.
May 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this computational study, researchers identified six phytochemicals, including Jamogenin, that effectively bind to the enzyme 5-AR, potentially promoting hair growth, and found that encapsulating Jamogenin in lipid nanoparticles enhances its stability.
This study concluded that phytotherapy offers a potentially effective and safer alternative to conventional treatments for androgenetic alopecia by reducing hair loss progression without the usual adverse effects.
December 2024 in “Skin Appendage Disorders” Researchers reviewed 13 clinical trials on non-prescription monotherapies like procyanidin and cetirizine for androgenetic alopecia, finding potential improvements in hair density and diameter, but emphasized the need for more robust trials to confirm efficacy and safety.
November 2024 in “Journal of Investigative Dermatology” Reishi mushroom extract may help treat hair loss.
July 2024 in “Skin Appendage Disorders” This study found that after 6 months of taking an oral supplement, patients with chronic telogen effluvium or androgenetic alopecia experienced a statistically significant increase in hair density and overall improved hair appearance compared to those taking a placebo, with the supplement being well tolerated.
January 2024 in “Brazilian Journal of Hair Health” This integrative literature review suggests that phytotherapeutic products, like Saw palmetto and Green tea, could serve as viable alternatives to current medications like finasteride for treating androgenetic alopecia, potentially offering fewer side effects.
January 2024 in “Estetologia Medyczna i Kosmetologia” In this study analyzing trichological shampoos on the Polish market, researchers reported that most active ingredients claimed to combat hair loss were found in only one product each, questioning the scientific evidence supporting these claims.
May 2019 in “Ukraïnsʹkij bìofarmacevtičnij žurnal” This study observed that the cream-mask and gel-mask with Serenoa repens and Sophora japonica applied to a rat model of androgenic alopecia stimulated hair follicle growth similarly to a reference minoxidil treatment.
January 2019 in “The Pharma Innovation Journal” This study found that optimal antioxidant properties of a cream-mask, as indicated by extended Paramecium caudatum motor activity in a toxic environment, were achieved with 10% Sophora japonica tincture and 5% Serenoa repens dry extract.
May 2018 in “Más dermatología” In this study, among postmenopausal women with female androgenetic alopecia, the combination of Pygeum africanum and Serenoa repens extracts at higher doses plus MSM significantly increased total hair growth and hair resistance compared to a lower dose formulation after 16 weeks.
January 2018 in “Hair transplant forum international” This article discusses a novel multi-targeting approach to treating hair loss using standardized nutraceuticals but reports no new clinical results.
September 2016 in “Más dermatología” New factors in female hair loss include genetics, hormones, stress, and inflammation; future treatments should also focus on these areas and consider the patient's emotional well-being.
October 2015 in “Elsevier eBooks” Chewing betel nut may increase the risk of type 2 diabetes, and saw palmetto can improve urinary symptoms in BPH with fewer side effects but may cause bleeding and allergic reactions.
January 2015 in “Hair therapy & transplantation” This review discusses natural and botanical products examined for treating alopecia and reports no clinical results; the authors note growing research interest in these treatments.
September 2014 in “Hair transplant forum international” This article discusses the role of transplantation in hair restoration but reports no new clinical findings.
January 2003 in “American Journal of Clinical Dermatology” In 2002, various skin reactions were reported due to different drugs, including allergies, hair loss, skin lesions, and other skin conditions.
February 2023 in “Current Pharmaceutical Design” This review explores medicinal plants as potential treatments for hair loss, suggesting their promise due to anti-inflammatory and antioxidant properties, but reports no new clinical results.
January 2022 in “Journal of Healthcare Sciences” This review discusses the epidemiology and available treatments for male androgenetic alopecia, noting that while current therapies can slow progression, they provide only partial hair restoration, and further research is needed for new strategies.
This review found inconsistent evidence on the effectiveness of oral finasteride for hair loss reversal in men with androgenetic alopecia, with one study showing significant results and others not.
68 citations
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April 2002 in “Journal of Alternative and Complementary Medicine” This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.
22 citations
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August 2009 in “Evidence-based Complementary and Alternative Medicine” This study found that a composition including Serenoa repens extract and anti-inflammatory agents effectively suppressed inflammation-related gene expression in a keratinocyte model, suggesting a potential dual strategy for treating androgenetic alopecia.
1 citations
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December 2006 in “Burns” New therapies for burn wounds show promise in reducing pain, infection risk, and improving healing and physical outcomes.
August 2025 in “Journal of Cosmetic Dermatology” This study found that a novel dietary supplement, AGA-P, when combined with minoxidil and finasteride, significantly improved the clinical efficacy of these drugs for treating mild-to-severe androgenic alopecia compared to drug treatment alone over six months.
January 2012 in “Курский научно-практический вестник "Человек и его здоровье"” In this study, indications for monotherapy with 5-alpha-reductase inhibitors, such as finasteride and herbal drugs, were developed based on clinical and morphological changes in patients with benign prostatic hyperplasia.
213 citations
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September 2020 in “Journal of Functional Biomaterials” This review discusses bio-based polymers, highlighting their potential in wound healing applications, but reports no new clinical results.