Optimization of Conservative Therapy Approaches for Benign Prostatic Hyperplasia with 5-Alpha Reductase Inhibitors: A Clinical and Morphological Study

    January 2012 in “ Курский научно-практический вестник "Человек и его здоровье" ”
    N. G. Kulchenkо
    TLDR 5-alpha-reductase inhibitors can effectively treat benign prostatic hyperplasia.
    The study, conducted on 65 patients, aimed to optimize conservative therapy for benign prostatic hyperplasia (BPH) using 5-alpha-reductase inhibitors, specifically finasteride and the herbal extract Serenoarepens. Over 6 months, both treatments significantly improved urinary symptoms and quality of life, with finasteride reducing the International Prostate Symptom Score (IPSS) by 22.2% and quality of life score by 30.2%, while Serenoarepens reduced IPSS by 30% and quality of life score by 18.7%. Both treatments also decreased prostate volume, with finasteride showing an 18.7% reduction and Serenoarepens 18%. The study highlighted the safety and tolerability of these treatments, although some finasteride users reported temporary sexual dysfunction. The findings supported the use of 5-alpha-reductase inhibitors in managing BPH, with finasteride showing notable morphological changes in prostate tissue, and emphasized a multidisciplinary approach in treatment selection.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Update: 4 Month progress on Fin/Min plus dermaroller

      in Progress Pictures  559 upvotes 1 year ago
      A user shared a 4-month update on their hair regrowth progress using finasteride, minoxidil, a dermaroller, ketoconazole shampoo, multivitamins, and biotin, and received positive reactions and inquiries from others. They also mentioned lifestyle changes such as quitting creatine, alcohol, and smoking, which may have contributed to their success.

      community Hair Loss Drugs Ranked in Order of Efficacy

      in Research/Science  67 upvotes 2 years ago
      Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

      community Wtf have we been doing for the last 30 years

      in Treatment  548 upvotes 11 months ago
      Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

    Similar Research

    6 / 1000+ results