Influence of Treatment with Alpha-Blockers and 5-Alpha Reductase Inhibitors on Morphological and Immunohistochemical Findings in Benign Prostatic Hyperplasia

    January 2002 in “ Dialnet (Universidad de la Rioja) ”
    Manuel Ruiz Roldan
    TLDR Finasteride treatment makes the prostate look more like a healthy one.
    This study investigated the effects of alpha-blockers and 5-alpha reductase inhibitors on benign prostatic hyperplasia (BPH) by examining morphological and immunohistochemical changes in the prostate. The research involved a sample of male subjects from Campo de Gibraltar, divided into four groups: a control group, BPH patients treated with alpha-blockers, those treated with 5-alpha reductase inhibitors, and patients who underwent surgery without prior medical treatment. Key findings included an average patient age of 68 years and a mean PSA value of 2.6 ng/dl. The stroma-epithelium ratio varied across groups, with the most significant change observed in the group treated with 5-alpha reductase inhibitors, where the glandular epithelium resembled that of healthy prostates.
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