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    Did you mean Benign Prostatic Hyperplasia?
    GlossaryBenign Prostatic Hyperplasia

    non-cancerous enlargement of the prostate gland common in older men

    Benign Prostatic Hyperplasia (BPH), also known as an enlarged prostate, is a non-cancerous increase in the size of the prostate gland. This condition is common in older men and can lead to urinary symptoms such as difficulty starting urination, a weak urine stream, and frequent urination, especially at night. BPH occurs due to hormonal changes and can be managed with medications, lifestyle changes, or surgical procedures if necessary.

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      learn Saw Palmetto

      a natural and far less effective alternative to Finasteride

      learn Bicalutamide

      a nonsteroidal anti-androgen, most commonly used orally for women

      learn Dutasteride

      Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

      learn Cyproterone

      a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      by nkrata in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community The closest thing to a cure before hair cloning or genetic via?

      in Treatment  9 upvotes 3 years ago
      The conversation discusses using finasteride or dutasteride to reduce DHT, CosmeRNA to target androgen receptors, and Minoxidil as a vasodilator for hair growth. The regimen aims to maintain hair by addressing DHT-AR ratio and continuous Minoxidil use.

      community 22 years since the last major development

      in Technology  51 upvotes 4 years ago
      The conversation discusses the lack of significant advancements in hair loss treatments since the introduction of finasteride 22 years ago, with many expressing frustration over the failure of new projects and skepticism about future developments. Some users mention hair transplants and other potential alternatives like Alfatradiol and Fluridil, but acknowledge finasteride's dominance in the market due to its effectiveness and affordability.