49 citations
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May 2020 in “Journal of Clinical Investigation” Exosomes are crucial for protecting sensory hair cells in the inner ear.
21 citations
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October 2017 in “Cell death and disease” Sesn2 protects inner ear hair cells from damage by regulating certain cell survival pathways.
44 citations
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March 2016 in “Frontiers in cellular neuroscience” Some natural compounds can protect fish ear cells from damage by certain antibiotics without affecting the antibiotics' ability to fight infections.
3 citations
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October 2021 in “Neuroscience Letters”
April 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” 71 citations
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January 2012 in “PloS one” The conclusion is that genetic differences affect how the cochlea heals after hair cell loss, which may challenge the creation of hearing loss treatments.
15 citations
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June 2019 in “eLife” Activin A and follistatin control when hair cells develop in mouse ears.
Activin A and follistatin control when ear hair cells form in mice.
Activin A promotes ear hair cell development, while follistatin delays it.
Activin A increases inner ear hair cell development, while follistatin decreases it.
28 citations
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June 2011 in “Hearing Research” Gene therapy, especially using atoh1, shows promise for creating functional sensory hair cells in the inner ear, but dosing and side effects need to be managed for clinical application.
5 citations
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July 2021 in “Basic & Clinical Pharmacology & Toxicology” Melatonin may protect ear cells from damage caused by nicotine.
63 citations
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January 1992 in “Experimental Neurology” Chickens exposed to loud noise can quickly regain hearing mostly due to repair of the tectorial membrane, not just hair cell regeneration.
4 citations
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December 2022 in “Frontiers in cell and developmental biology” Zebrafish larvae are used to study and find treatments for ear cell damage because they are easier to observe and test than mammals.
1 citations
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February 2010 in “Proceedings of SPIE” Low level laser therapy may help regenerate hair cells in the ear after damage from gentamicin.
66 citations
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February 2015 in “Cell & tissue research/Cell and tissue research” The document concludes that there are no effective clinical treatments for hearing loss due to hair cell damage, but research is ongoing.
11 citations
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January 2011 in “Developmental neurobiology” Ptprq has multiple forms that change during inner ear development.
21 citations
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June 2016 in “PloS one” Zebrafish need MYC and FGF to regenerate inner ear hair cells.
March 2024 in “Biochimica et biophysica acta. Molecular basis of disease” Deferoxamine may help protect inner ear cells from damage caused by oxidative stress.
January 2024 in “Biological Research” Tiny particles from stem cells can help protect ear cells from antibiotic damage by helping cells remove damaged parts.
16 citations
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February 2022 in “Science Advances” Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.
April 2024 in “Archives of toxicology” Certain substances can protect against ear damage from some antibiotics in zebrafish.
A low dose of rapamycin increases inner ear hair cell creation by boosting SOX2+ cell numbers.
44 citations
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February 2012 in “The journal of neuroscience/The Journal of neuroscience” Mutations in the PTPRQ gene cause significant balance issues in mice due to hair bundle defects in the inner ear.
1 citations
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January 2016 in “Elsevier eBooks” SOX2 is crucial for skin cell function and hair growth, and it plays a role in skin cancer and wound healing.
19 citations
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September 2019 in “Expert Opinion on Therapeutic Targets” New treatments for hair loss may target specific pathways and generate new hair follicles.
2 citations
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September 2023 in “Development” Hair follicles in the back of the rosette fancy mouse have reversed orientations due to a gene mutation.
77 citations
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September 2004 in “Gene expression patterns” The three estrogen receptor genes are highly expressed in zebrafish neuromasts during development.
6 citations
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November 2018 in “Histochemistry and Cell Biology” Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.
September 2021 in “Research Square (Research Square)” Not having enough or having too much of the protein Grainyhead-like 3 leads to various developmental problems.