1 citations
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August 2023 in “Journal of cosmetic dermatology (Print)” This review discusses the potential link between selenium supplementation and symptoms of chronic selenium toxicity, such as hair loss and nail dystrophy, due to excess intake leading to disruptions in hair and nail protein structure.
September 2023 in “Food and chemical toxicology” In this study on Sprague-Dawley rats, 0.60 mg/kg doses of L-Se-methylselenocysteine and sodium selenite were associated with liver toxicity and reduced sperm motility, while Se-enriched peptides showed no observable adverse effects up to 0.60 mg/kg.
February 2024 in “Exposure and Health” Selenium supplements may reduce mercury levels in the hair of city dwellers in China.
71 citations
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June 2008 in “Annals of Internal Medicine” This article describes a case of selenosis linked to excessive selenium in a nutritional supplement that led to a product recall due to toxicity concerns.
76 citations
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April 2002 in “Urology” This review examines the use of selenium and vitamin E supplements for reducing prostate cancer risk, finding mixed evidence that suggests benefits may be limited to individuals with specific risk factors, like low baseline levels or smoking history, rather than broadly applicable.
1 citations
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February 2021 in “Animal feed science and technology” This study found that puppies fed organic selenium had better retention of selenium compared to those fed inorganic selenium, with no significant difference in coat quality or hair growth.
February 2024 in “Animals” This study found that supplementing pregnant Hanshan white cashmere goats' diets with selenium yeast led to higher birth weights, improved cashmere quality and yield, and enhanced hair follicle development in their offspring, possibly through increased antioxidant capacity.
27 citations
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June 2010 in “Journal of the American Academy of Dermatology” Excessive selenium in supplements can cause hair loss and nail issues.
79 citations
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April 1996 in “JAMA” This article describes a case of selenium poisoning in a 36-year-old man who experienced hair loss, nail changes, and paresthesias after taking selenium-containing vitamin tablets.
78 citations
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December 2011 in “Clinical toxicology” This study describes a case series of nine patients experiencing symptoms of selenium toxicity after consuming a liquid dietary supplement with an excess amount of selenium.
382 citations
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February 2010 in “Archives of Internal Medicine” This study identified that high concentrations of selenium in a liquid dietary supplement caused a widespread outbreak of poisoning, revealing the importance of stricter manufacturing standards.
18 citations
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September 2011 in “Livestock science” This study found that maternal Nano-Se supplementation in cashmere goats improved antioxidant status and promoted secondary hair follicle development in fetuses at 110 days.
June 2023 in “Skin Research and Technology” The researchers reported that an oral supplement containing hydrolysed fish-origin collagen, taurine, cysteine, methionine, iron, and selenium significantly improved the effectiveness of anti-hair loss treatments in people with androgenic alopecia or chronic telogen effluvium after 12 weeks, compared to drug treatments alone.
February 2026 in “Pakistan Veterinary Journal” In this study of White cashmere goat ewes and their offspring in Tibet, selenium and vitamin E supplementation improved antioxidant capacity and serum biochemical indices and enhanced secondary hair follicle development in lambs, but did not significantly alter fecal microbiota composition.
15 citations
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July 1984 in “Nutrition Research” Selenium increased in hair but not in blood after taking supplements.
In this study, women with acute telogen effluvium taking the Hair’InsideTM supplement for 84 days showed significant improvements in hair regrowth, shedding, brightness, and volume compared to placebo, with no reported adverse effects.
126 citations
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November 1987 in “The Journal of Pediatrics” This study reports that selenium deficiency in children on long-term total parenteral nutrition may lead to symptoms like erythrocyte macrocytosis and skin and hair depigmentation, which improved with selenium supplementation.
This book chapter discusses the mechanisms and prevention of selenium toxicity in livestock and reports no new experimental results; it emphasizes reducing selenium in the human food chain through animal products.
This source highlights concerns about the safety and efficacy of dietary supplements marketed for hair loss, citing a lack of FDA testing and potential risks such as adverse side effects, interference with medical tests, and withholding of ingredient information.
This review discusses the potential benefits of the Restolin Hair Supplement for hair growth and reports no clinical results, with the authors noting that the claims are not supported by FDA approval or clinical trials.
January 2026 in “Updates in clinical dermatology” Proper nutrition and alternative therapies can help manage hair loss.
May 2023 in “Elsevier eBooks” This source highlights the increasing use of nutritional supplements among patients with androgenetic alopecia, noting positive effects on hair thickness and density in controlled trials, while emphasizing the need for further research to understand their safety and efficacy.
30 citations
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January 2023 in “EFSA journal” This review establishes a tolerable upper intake level of 255 μg/day for selenium in adults, warning that supplements and Brazil nuts may cause excess intake.
7 citations
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October 2020 in “Dermatology practical & conceptual” This review discusses the potential risks associated with skin, hair, and nail supplements, highlighting concerns about safety, efficacy, and lack of regulation but reports no new clinical results.
1 citations
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May 2019 in “Annals of Medicine” In this study, researchers found that most food supplement labels in Portugal recommend daily mineral doses exceeding the EU's Recommended Daily Allowance, with some even surpassing the Tolerable Upper Intake Level, raising safety concerns regarding potential adverse effects.
April 2016 in “Journal of The American Academy of Dermatology” A vitamin and mineral supplement significantly reduced hair shedding in Brazilian women with telogen effluvium.
79 citations
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January 2017 in “Dermatology practical & conceptual” This article addresses the need to screen for nutrient deficiencies in patients with hair loss but reports no new findings, noting that supplementation without deficiency may not be beneficial and could pose risks.
This study highlights the increasing association between popular diets, unregulated supplements, and various skin disorders, emphasizing the need for clinicians to thoroughly assess dietary histories to manage nutrition-related skin issues effectively.
14 citations
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October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.