January 2023 in “Voennaâ medicina” This case study illustrates the successful treatment of chronic diffuse telogen effluvium in a young woman attributed to latent iron deficiency and emphasizes the importance of comprehensive assessment in similar cases.
December 2021 in “Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk” In this study, personalized treatment of folic acid and vitamin E deficiencies improved hair parameters in AGA patients, while Se supplementation might be unnecessary.
70 citations
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June 2010 in “Clinics in Dermatology” This review discusses how changes in hair and skin may indicate underlying vitamin deficiencies and emphasizes the need to identify populations at risk for these deficiencies; it reports no new results.
13 citations
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January 2012 in “International Journal of Trichology” This study reports a case where excessive consumption of "paradise nuts" led to acute selenium toxicity and massive hair loss.
July 2008 in “International Society of Hair Restoration Surgery” This report warns that the Total Body Mega Formula nutritional supplement may cause selenium toxicity leading to significant hair loss.
October 2025 in “Jurnal Ilmiah Kedokteran dan Kesehatan” This literature review reports that multivitamin supplementation can enhance hair density and quality in people with suboptimal nutritional status but warns that excessive intake of certain vitamins and minerals may cause hair loss.
March 2024 in “CRC Press eBooks” This chapter reviews hormonal imbalances and related disorders, discussing nutraceuticals—such as cod liver oil, green tea, and Omega-3s—that may alleviate symptoms and improve hormonal fluxes in lieu of traditional synthetic treatments that have potential side effects.
27 citations
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September 2017 in “Journal of Medicinal Food” In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.
618 citations
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January 2018 in “Cochrane Database of Systematic Reviews” This study reported that selenium supplements do not reduce cancer risk and may increase the risk of type 2 diabetes and high-grade prostate cancer, while observational studies suggest mixed associations between selenium exposure and cancer incidence.
127 citations
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March 2004 in “Gynecologic oncology” This study concluded that selenium supplementation for ovarian cancer patients during chemotherapy may have several beneficial effects, such as increased antioxidant enzyme activity, reduced chemotherapy-related symptoms, and higher selenium levels in serum and hair.
1 citations
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March 2020 in “̒Ulūm-i dārūyī” This study found that one month of selenium supplementation improved liver and kidney function biomarkers and reduced severe hair loss in patients with beta-thalassemia major.
April 2024 in “Research Square (Research Square)” In this randomized trial, lupus patients taking daily 200 μg selenium supplements for eight weeks showed significant improvements in metabolic markers like CRP, ESR, MDA, and GPX, as well as reduced clinical symptoms such as arthritis and alopecia, compared to those receiving a placebo.
October 2009 in “The American Journal of Gastroenterology” This report describes a case where selenium supplementation in excess may have led to toxic liver injury, suggesting that high-dose selenium can cause hepatic necrosis.
93 citations
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March 2014 in “Cochrane Database of Systematic Reviews” This review concludes that although observational studies suggest a potential inverse association between selenium exposure and cancer risk, randomized trials show no convincing evidence that selenium supplements prevent cancer in humans and may indicate harmful effects.
21 citations
,
June 1991 in “Journal of Inherited Metabolic Disease” This case report observed that a selenium-deficient diet in a child with propionic acidaemia led to macrocytosis and hair abnormalities, which improved with selenium supplementation.
1 citations
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January 2018 in “Molecular and integrative toxicology” This review discusses the dual role of selenium in human health, highlighting both the dangers of deficiency and potential toxicity from over-supplementation, without presenting new clinical results.
2 citations
,
October 1961 in “Experimental Biology and Medicine” This study found that rabbits fed a diet deficient in Vitamin E developed severe muscular dystrophy that was not fully prevented by adding selenium, Vitamin E supplements, or natural feedstuffs, indicating other nutritional deficiencies.
3 citations
,
August 2004 in “Veterinary Dermatology” This study observed that supplementing with vitamins, iodine, cobalt, and selenium prevented hair follicle growth arrest in Icelandic horses during winter.
31 citations
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September 2010 in “Current Opinion in Clinical Nutrition & Metabolic Care” This review discusses the lack of specific micronutrient supplementation recommendations for hair loss in patients on long-term parenteral nutrition and reports no new clinical results.
April 2015 in “The FASEB Journal” This study suggests that selenium deficiency accelerates aging-related health deterioration in mice with short telomeres, providing a model for exploring selenium’s role in human aging.
This study found that certain dietary changes, such as a low glycemic load diet for men and specific supplements for women, may improve acne, while chocolate, whey proteins, and dairy products are linked to worsened symptoms in both genders.
2 citations
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March 2013 in “BMJ Case Reports” In this case study, zinc deficiency persisted despite supplementation in a patient with severe malnutrition and empyema, potentially due to nutrient absorption competition and proton pump inhibitor use.
7 citations
,
January 2017 in “Journal of cosmetology & trichology” This article discusses how nutritional and environmental factors, along with antioxidant supplementation, may improve hair growth by mitigating the effects of androgens and reports no new clinical results.
63 citations
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March 2000 in “Annals of clinical psychiatry” This article reviews the association between psychopharmaceuticals and medication-induced alopecia, noting that hair regrowth typically occurs after discontinuing or reducing the medication, while mineral supplements' effectiveness remains unclear.
61 citations
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May 2010 in “Integrative Cancer Therapies” This review discusses the potential benefits and risks of selenium in cancer prevention and treatment, emphasizing that while selenium may offer advantages for tumor patients, further research is needed due to mixed findings regarding diabetes risk.
16 citations
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May 2019 in “Hormone and Metabolic Research” This systematic review found insufficient evidence to support protective effects of selenium on polycystic ovary syndrome complications, despite some studies suggesting it may reduce insulin resistance and dyslipidemia.
February 2023 in “European journal of geriatrics and gerontology” Selenium helps prevent thyroid issues and cognitive decline in the elderly, but balance is key.
63 citations
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May 2017 in “American Journal of Clinical Dermatology” This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.
November 2024 in “Journal of Education Health and Sport” This study reviewed different hair loss treatments and suggested that microneedling, PRP therapy, hair transplantation, and certain pharmacological and supplementation approaches show varying effectiveness, with some needing further research for confirmation.
This article provides an overview of various selenium-based products, their uses in treating conditions from cancer to dandruff, and lists potential adverse effects and interactions, but reports no new results.