Adverse Cutaneous Reactions to Mood Stabilizers

The document from 2003 reviewed adverse cutaneous drug reactions (ACDRs) to mood stabilizers, highlighting the high incidence of severe and life-threatening ACDRs associated with these medications. It discussed common reactions like pruritus and alopecia, as well as severe reactions such as erythema multiforme and Stevens-Johnson syndrome. The review stressed the importance of careful monitoring for ACDRs, slow dose escalation, and patient education on the risks of mood stabilizers. It also noted the lack of clinical evidence for zinc and selenium supplementation in treating drug-induced alopecia. Clinicians were advised to be cautious of cross-sensitivity between anticonvulsant medications and to consider drug interactions when prescribing mood stabilizers. The document emphasized the necessity of immediate medical intervention and discontinuation of the offending agent in the case of severe ACDRs.