Clinical Role of Oral Vitamin C and E Therapy in Skin and Hair Disorders

The document "Clinical Role of Oral Vitamin C and E Therapy in Skin and Hair Disorders" presents a study involving 500 participants and a review of 58 articles involving 1,669 patients. The study showed that oral Vitamin C and E supplementation significantly improved skin elasticity and hydration, reduced skin wrinkling, increased hair growth, and decreased hair loss over a 6-month period. The review found evidence supporting the use of these vitamins in treating pigmentary disorders like chloasma and fibrotic disorders like radiation-induced fibrosis, especially when used in combination. However, the evidence is limited and inconsistent, with many studies having small sample sizes and being conducted before 1980. High doses of vitamin E (greater than 400 IU per day) are associated with an increase in all-cause mortality. The authors recommend larger, more recent studies for definitive support.