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Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Cathepsin L is essential for normal hair growth and development.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Stress can worsen skin conditions by affecting hormone levels and immune response.

Different scaffold patterns improve wound healing and immune response in mouse skin, with aligned patterns being particularly effective.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.