The Role of Cytochrome P-450 in Dermatology

The 1989 document discussed the role of cytochrome P-450 (P450) isozymes in dermatology, particularly in the metabolism of skin-related compounds and the potential therapeutic applications for treating various skin conditions. P450 isozymes are involved in the metabolism of lipophilic compounds and xenobiotics in the skin and liver. The paper highlighted the use of P450 inhibitors, such as azole antifungals, in treating fungal infections, psoriasis, androgenic skin disorders like hirsutism and androgenic alopecia, acne, eczema, and potentially in preventing skin cancer. It suggested that genetic variations in P450 isozymes could explain hereditary patterns in skin disorders and emphasized the need for further research to develop specific azole derivatives that selectively inhibit P450 isozymes involved in these conditions. Ketoconazole was mentioned as an example of a P450 inhibitor with some therapeutic effects but was not considered a universal solution.