research Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.
This study identified CYP3A4 as a key isozyme involved in the oxidative metabolism of finasteride in human liver microsomes.
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5 / 1000+ resultsresearch The Role of Cytochrome P-450 in Dermatology
This review discusses the role of Cytochrome P-450 in dermatology and reports no new clinical results.
research Clinically-Relevant Chemotherapy Interactions with Complementary and Alternative Medicines in Patients with Cancer
This study discusses clinically relevant interactions between anticancer drugs and herbal medicines used by cancer patients, highlighting potential herb-drug interactions and emphasizing the need for careful monitoring to minimize risks.
research Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition
Finasteride effectively blocks rat enzymes, but with varying methods and strength.
research Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-Reductase: evidence for mechanism-Based inhibition by finasteride
This study concludes that rhesus macaques are a suitable model for testing the pharmacological properties of finasteride and other 5aR inhibitors, due to their biochemical similarity to humans.
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