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research Testosterone, cytochrome P450, and cardiac hypertrophy

155 citations , October 2002 in “The FASEB Journal”

This study found that altered testosterone metabolism and changes in cytochrome P450 mono-oxygenase expression are significantly associated with cardiac hypertrophy in human hearts and spontaneously hypertensive rats.

research Neurosteroids and epileptogenesis in the pilocarpine model: Evidence for a relationship between P450scc induction and length of the latent period

62 citations , January 2009 in “Epilepsia”

In this study, status epilepticus in rats induced P450scc in hippocampal glia, which was associated with a delayed onset of spontaneous seizures, while inhibiting neurosteroid synthesis accelerated seizure onset if P450scc was significantly increased.

research Comparison of Activities Dependent on Glutathione S-Transferase and Cytochrome P-450 IA1 in Cultured Keratinocytes and Reconstructed Epidermal Models

42 citations , January 2002 in “Skin Pharmacology and Physiology”

This study reported that reconstructed skin models can be useful for studying the effects of non-water-soluble topical products on xenobiotic metabolism, particularly in enzyme activities like EROD and GST.