Sox9 Expression in Canine Epithelial Skin Tumors
July 2015
in “
European journal of histochemistry
”
Sox9 canine epithelial skin tumors immunohistochemical staining neoplasms subungual keratoacanthoma malignant tumors hair follicles trichoblastomas hair follicle stem cells basal cells suprabasal cells tricholemmomas trichoepitheliomas squamous cell carcinomas diagnostic marker therapeutic target molecular mechanisms stem cell biology skin tumors hair follicle tumors skin cancer stem cells
TLDR Sox9 is present in most canine skin tumors and may help understand stem cells' role in these cancers.
The study investigated Sox9 expression in 11 types of canine epithelial skin tumors using immunohistochemical staining, finding that Sox9 was expressed variably in all examined neoplasms except subungual keratoacanthoma. Higher Sox9 levels were observed in malignant tumors and those related to hair follicles, such as trichoblastomas, indicating a strong link between Sox9 and hair follicle stem cells. Sox9 was prominent in basal and suprabasal cells of tricholemmomas and trichoepitheliomas, while squamous cell carcinomas showed irregular positivity. The findings suggested Sox9 as a potential diagnostic marker and therapeutic target, contributing to a better understanding of the molecular mechanisms and stem cell biology of canine skin tumors.
