9 citations
,
November 2018 in “Drug Discovery Today” This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.
April 2023 in “The Egyptian Journal of Histology” This study found that platelet-rich plasma improved healing and accelerated scar maturation in rat models of second-degree skin burns, especially noticeable after four weeks of treatment.
July 2025 in “Burns & Trauma” In this study, researchers developed a new SFL-3D system to produce extracellular vesicles from rejuvenated dermal papilla cell spheroids, which demonstrated significant antifibrotic effects in reducing hypertrophic scarring, highlighting their potential for precision-targeted scar management.
3 citations
,
August 2024 in “Journal of Cosmetic Dermatology” This study found that using ablative fractional CO₂ laser therapy combined with FUE treatment in patients with post-traumatic eyebrow scars and defects improved follicular survival rates and resulted in well-defined eyebrow shapes.
232 citations
,
December 2011 in “Journal of the American Academy of Dermatology” Understanding and targeting specific molecules can help reduce scarring and promote scar-free healing.
8 citations
,
January 2022 in “Burns and trauma” This review discusses the role of extracellular vesicles from specific skin cells in wound healing, emphasizing their potential in regenerative medicine and reporting no new experimental results.
February 2026 in “Exploration” This review summarizes research on scar formation and inhibition mechanisms, discussing emerging therapies like gene therapy and stem cell treatments, but notes ongoing challenges for clinical application, including treatment personalization and outcome sustainability.
This study found that grafting an autologous cultured epithelial sheet improved both scarring and skin texture in four patients with acne-associated scar contracture three months post-treatment, suggesting the technique might effectively treat difficult acne scars by metabolizing excess collagen.
78 citations
,
June 2021 in “Dermatology and Therapy” This study highlights the evolving understanding of acne's pathophysiology and suggests that targeting pro-inflammatory cytokines such as IL-1β, IL-17, IL-23, and TNFα with biological antibodies may offer new treatment strategies for severe acne and its scars.
31 citations
,
January 2019 in “Frontiers in Veterinary Science” This study found that low-level laser therapy at 8 J/cm2 improved cosmetic surgical scar healing in canines after thoraco-lumbar hemilaminectomy compared to controls.
10 citations
,
February 2021 in “Pharmaceutics” In this study, the novel fatty acid-conjugated tetrapeptide Palmitoyl-GDPH enhanced wound healing in rats by improving re-epithelialization and collagen deposition with minimal toxicity observed at the used dosage.
June 2026 in “Preprints.org” This review examines the mechanisms behind pathological scarring like hypertrophic scars and keloids, highlights the limitations of current treatments, and suggests that biomaterial-enabled delivery of anti-fibrotic statins, such as atorvastatin, may offer a promising therapeutic avenue for managing these scars.
14 citations
,
September 2017 in “Clinical and Experimental Dermatology” In this report, a 26-year-old man with folliculitis decalvans unresponsive to standard treatments experienced significant disease clearance after 25 months of systemic photodynamic therapy, marking the first documented use of this therapy for this condition.
5 citations
,
December 2018 in “Annals of plastic surgery” In this report, seven burn patients developed hypertrichosis after undergoing pressure garment/silicone therapy intended to prevent hypertrophic scarring.
1 citations
,
December 2025 in “Journal of Pharmacology and Experimental Therapeutics” Exosomes show promise in improving skin health and appearance.
August 2024 in “Indian Journal of Skin Allergy” This review outlines the current state of stem cell therapy in dermatology, highlighting its potential for treating a variety of skin disorders and conditions, while emphasizing the need for further controlled studies to standardize treatment and fully understand its efficacy and limitations.
June 2021 in “Dermatologic surgery” This review discusses the measurement of patient satisfaction in acne scar treatment studies, highlighting the need for standardized satisfaction questions to enhance comparability and future research; it reports no new clinical results.
1 citations
,
May 2010 in “Chinese journal of plastic surgery” This study found higher expression of melatonin receptors in fibroblasts of human hypertrophic scars compared to normal skin, suggesting a possible link to scar development.
February 2025 in “Dermatologic Surgery” This review highlights the expanding medical applications of follicular unit excision, suggesting it might be effective for conditions like chronic ulcers, axillary hyperhidrosis, bromhidrosis, vitiligo, and scar remodeling, although further research is needed.
18 citations
,
June 2018 in “Journal of The American Academy of Dermatology” This review found that existing studies on adipose tissue for scarring, wound healing, and hair growth show some positive outcomes, but the evidence is insufficient to change current dermatological practices.
3 citations
,
January 2021 in “Skin appendage disorders” This study reports anagen hair loss four weeks after scalp surgeries, likely due to transient ischemia, and emphasizes the importance of informing patients about potential hair loss and recovery within three months.
1 citations
,
October 2025 in “International Journal of Nanomedicine” This review explores the potential for using exosomes in treating autoimmune skin diseases and promoting skin regeneration, highlighting current applications, delivery methods, and ongoing clinical trials while also identifying challenges and future research directions within dermatology.
14 citations
,
July 2009 in “Current Opinion in Otolaryngology & Head and Neck Surgery” This review discusses recent developments in hair restoration, highlighting the continued prominence of follicular unit strip surgery and the growing literature on the relatively new technique of follicular unit extraction, without presenting new clinical results.
This narrative review highlights the potential of exosomes in regenerative and aesthetic dermatology, particularly in India, but emphasizes that their clinical use is still investigational due to limited and diverse study data, insufficient long-term safety information, and regulatory challenges.
40 citations
,
June 2013 in “Molecular Pharmaceutics” This study demonstrates that transfected epidermal stem cells using a novel 3D transfection system significantly enhanced wound healing and may serve as an effective therapeutic agent and gene delivery method for wound treatment.
April 2008 in “Medical & surgical dermatology” Certain hairstyles can cause scalp diseases, smoking is linked to hair loss, 5% minoxidil foam is effective for hair loss treatment, and various factors influence wound healing and hair growth.
178 citations
,
August 2016 in “Advances in wound care” This article discusses advancements in understanding how skin stem cells and fibroblasts contribute to scar formation, highlighting current and potential therapies aimed at preventing or reducing scarring, yet notes that effective treatments without significant side effects are still lacking.
10 citations
,
July 2011 in “Wound Repair and Regeneration” This article proposes several potential approaches for scar prevention and therapy, including anti-transforming growth factor-β strategies and tissue-engineered skin, but reports no new clinical results.
In this narrative review, the authors explored various rehabilitative techniques, including injections and physical therapies, that may enhance aesthetics and psychosocial wellbeing in patients with disabilities, emphasizing a multidisciplinary approach to improve both functional and cosmetic outcomes.
113 citations
,
July 2015 in “Journal of Cosmetic Dermatology” This review discusses the cosmetic applications of platelet-rich plasma in dermatology, highlighting its potential benefits and the need for more controlled studies.