June 2023 in “Research Square (Research Square)” In this study, utilizing a mixture of crushed sky fruit seeds and sodium salt for goat skin preservation led to a significant reduction in environmental impact, decreasing total dissolved solids by 59% and chloride content by 44%, while maintaining the physical quality of processed leather.
This study found that Solanum nigrum L. extracts showed potential as 5 alpha-reductase inhibitors, similar to finasteride, and highlighted their promise for treating androgenic diseases like benign prostatic hyperplasia and male pattern hair loss.
104 citations
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January 2005 in “Climacteric” This review discusses the pharmacological properties of progestins used in contraception and hormone replacement therapy, focusing on drospirenone's unique effects, but reports no new experimental findings.
This study suggests that 9-Octadecenoic acid (Z)-, 2,3-dihydroxypropyl ester from African Yam bean seeds may inhibit the human 5α-reductase II enzyme, potentially helping manage BPH, although further studies are needed.
February 2026 in “Toxicology Letters” This study used an in silico/in vitro approach to identify potential inhibitors of the enzyme SRD5A2, finding that the androgen receptor modulator MK-0773 is a moderate inhibitor, although it does not act as a covalent inhibitor like finasteride.
50 citations
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August 1985 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry” This study found that spironolactone directly inhibits 5 alpha-reductase activity in hirsute women, resulting in decreased conversion of testosterone to dihydrotestosterone, which may contribute to its therapeutic effects.
2 citations
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November 2025 in “Plant Molecular Biology”
In this study, researchers discovered that the Fusarium sp. strain K23 fungus enhances salt-stress tolerance in Arabidopsis thaliana by promoting root hair development, suggesting a potential strategy to combat soil salinity issues in agriculture.
April 2025 in “Antioxidants” In this study, the researchers found that the water-soluble fraction of Rhus semialata gall extract and its component Penta-O-Galloyl-β-D-Glucose promoted hair growth in human dermal papilla cells, and clinical trials supported these findings, showing improved hair density and appearance compared to placebo.
December 2016 in “University of Birmingham Institutional Research Archive (University of Birmingham)” This study found that manipulating 5αR2 activity in human hepatocytes in vitro can regulate lipogenesis, with potential clinical implications for patients taking 5αR inhibitors.
2 citations
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December 2021 in “Asian Journal of Beauty and Cosmetology” This study reported that a specific mixing ratio of Dendropanax extract and sea salt showed low cytotoxicity, high cell proliferation, anti-inflammatory, and antimicrobial effects, suggesting potential for functional cosmetics against hair loss.
6 citations
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May 2022 in “Research and reports in urology” This study found that Caesalpinia bonduc seed extracts significantly reduced prostate weight and improved prostate tissue morphology in Wistar rats with testosterone-induced benign prostatic hyperplasia.
May 2021 in “Boletín latinoamericano y del Caribe de plantas medicinales y aromáticas” This study found that ethanolic extracts of Microsechium helleri showed notable antioxidant, hypoglycemic, and cardioprotective activities, while chloroformic extracts exhibited significant anti-inflammatory effects in experimental models.
September 2019 in “Journal of Investigative Dermatology” This study reports that thermography and high-frequency ultrasound show promise as diagnostic tools for personalizing treatment plans in atopic dermatitis and psoriasis vulgaris by assessing skin lesion characteristics.
184 citations
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October 2007 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that sulforaphane-rich broccoli sprout extracts reduced UV-induced erythema by 37.7% in humans, suggesting a protective strategy against UVR damage.
November 2025 in “Contact Dermatitis” In this case study, a 34-year-old woman experienced facial allergic reactions to SPF-containing products, and patch tests identified sensitization to salicylates, which when avoided, stabilized her symptoms and her existing frontal fibrosing alopecia, highlighting a possible link to investigate further.
August 2023 in “Innovare journal of Ayurvedic sciences” In this in vitro study, methanolic extracts of Mangifera indica and Hibiscus rosa-sinensis demonstrated significant inhibitory activity on α-amylase and α-glucosidase enzymes, suggesting their potential usefulness in diabetes management due to their comparable effects to the standard drug acarbose.
January 2022 in “Current Enzyme Inhibition” This study found that two novel nonsteroidal derivatives inhibited specific enzymes in vitro and in vivo, leading to dihydrotestosterone accumulation in androgen-dependent glands, suggesting potential therapeutic use for mood improvement in the elderly.
November 2022 in “Medicina Estética Revista Científica de la Sociedad Española de Medicina Estética (SEME)” This study aimed to evaluate the effectiveness of a hair conditioner containing Serenoa serrulata extract and tocoferol applied 3-4 times per week for 90 days against androgenic alopecia.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, in silico analysis identified Saponin Re and Emodin as promising candidates for topical treatment of androgenetic alopecia, with Biochanin A having the most favorable safety profile among the tested compounds.
2 citations
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January 2019 in “Biomedical Journal of Scientific and Technical Research” This article describes the growth and characteristics of saw palmetto and its fruit but reports no new research results.
January 2026 in “International Journal of Biological Macromolecules” 9 citations
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June 2022 in “Plants” This study found that shallot extract may promote hair growth in androgenetic alopecia by reducing inflammation and modulating gene expression related to key hair growth pathways.
4 citations
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March 1968 in “The Lancet” The study observed unexpected blue fluorescence in urine linked to salicylate metabolite presence, suggesting "aspirin addiction" in patients with unexplained hair loss, potentially tied to chronic disease or hair production interference.
15 citations
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June 2018 in “Journal of Chromatographic Science” This study successfully developed a method to measure four flavonoids from Platycladus orientalis leaves in rat plasma, which was used in a pharmacokinetic study on healthy rats.
March 2023 in “International Journal of Applied Pharmaceutics” In this study, researchers formulated a topical gel containing β-sitosterol for alopecia treatment and found it demonstrated good 5 alpha reductase inhibitory activity in vitro, comparable to a commercial product, indicating its potential for further antiandrogenic activity investigation.
2 citations
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March 2021 in “Journal of nanoscience and nanotechnology” This study suggests that nanoliposomes encapsulating saw palmetto CO2 extract could be effective for delivering drugs to treat hair loss due to their small size, dispersion, and negative charge.
February 2026 in “Molecules” This study reported that a novel nanomedicine combining berberine and sinapic acid significantly inhibited the growth of mouse mammary carcinoma cells and demonstrated an anti-tumor effect in vivo, without significant systemic toxicity after 28 days, suggesting a promising, low-toxicity therapeutic strategy for breast cancer.
196 citations
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December 2017 in “Phytotherapy Research” This review discusses the bioactive phytochemical and biological activities of Psoralea corylifolia, emphasizing its potential therapeutic uses, and reports no new clinical results; the authors call for further clinical trials.
October 2022 in “International journal of pharmaceutical sciences review and research” This study compared the antioxidant and antidiabetic activities of Hibiscus rosa-sinensis leaf extract and Eclipta alba bark extract, finding that Hibiscus rosa-sinensis exhibited greater antidiabetic activity, whereas Eclipta alba demonstrated stronger antioxidant activity.