68 citations
,
December 1991 in “Annals of the New York Academy of Sciences” Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
13 citations
,
April 1994 in “Journal of Investigative Dermatology” Androgen receptors found in monkey scalps, similar to humans, affect hair growth.
4 citations
,
January 2018 in “Advances in Experimental Medicine and Biology” This article discusses the structures surrounding hair follicles and introduces aspects like follicle groups and the dermal sheath, but it reports no new research findings.
1 citations
,
January 2009 in “Journal of Dermatology and Venereology” This study found that cells from the upper hair follicle exhibited more active growth compared to other segments in vitro, suggesting their potential as a source of hair follicle stem cells.
April 2021 in “Journal of Investigative Dermatology” This study suggests that edelweiss extract may promote hair growth and reduce shedding in ex vivo experiments by affecting hair follicle anagen phase duration and keratinocyte proliferation.
October 2019 in “Skin appendage disorders” This study revisits and reproduces Felix Pinkus' concept of the vitreous membrane in hair follicles, suggesting these structures may play a role in differentiation or nutrition due to their location in metabolically dynamic regions.
February 2010 in “Journal of the American Academy of Dermatology” Activating cAMP and ATP improves hair growth and strength.
September 2007 in “PubMed” This study observed that subcutaneously implanted mixtures of human hair follicle cells in nude mice resulted in the formation of hair follicle-like structures, suggesting potential for hair regeneration.
January 2007 in “Chinese journal of plastic surgery” In this study, researchers observed that sodium selenite may counteract the pro-apoptotic effects of sodium fluoride on human scalp hair follicle cells in vitro.
356 citations
,
December 1986 in “The journal of cell biology/The Journal of cell biology” This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.
228 citations
,
January 1997 in “Birkhäuser Basel eBooks” This article integrates existing literature on hair follicle structure and formation at the cellular and molecular level, reporting no new findings.
149 citations
,
June 2010 in “The FASEB journal” In this study, miR-31 was found to play a significant role in hair cycle regulation in mice by controlling key gene expressions involved in hair growth and differentiation.
139 citations
,
December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a new type II cytokeratin, named K6hf, exclusively expressed in the companion layer of the human hair follicle, distinguishing it from other keratins and suggesting a unique biochemical role.
124 citations
,
November 2000 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that human peptidylarginine deiminase type III is the predominant isoform in hair follicles and may modulate structural proteins during hair and hair follicle formation.
116 citations
,
April 1986 in “The journal of cell biology/The Journal of cell biology” This study reports that a 190,000 molecular weight protein, identified as trichohyalin, may play a matrix role in the development of inner root sheaths in hair follicles.
103 citations
,
February 1972 in “Proceedings of the National Academy of Sciences” This study found that a unique transglutaminase in guinea pig hair-follicles, distinct from liver transglutaminase, likely plays a role in forming protein cross-links via ε(γ-glutamyl)lysine bonds.
88 citations
,
July 1958 in “Nature” This study reported the first known occurrence of citrulline in an animal protein, specifically in the fibrous protein of hair follicle inner root sheaths.
85 citations
,
October 2007 in “International Journal of Dermatology” In this study, researchers found that the curliness of human hair is associated with an asymmetric structure at the cellular level, particularly in the differentiation of the precortex.
85 citations
,
February 1989 in “Journal of The American Academy of Dermatology” This case report describes a newly identified condition called loose anagen hair of childhood, characterized by easily pluckable hair in two young boys, with variable duration and no scalp inflammation or scarring.
84 citations
,
April 2002 in “Archives of Dermatology” This study found that a keratin mutation may cause diffuse partial woolly hair associated with loose anagen hair syndrome in some families, but other genetic factors could play a role in different cases.
70 citations
,
December 2004 in “Differentiation” This study identifies six novel keratin genes from the chromosome 17q21.2 region, suggesting their association with hair follicles, while all 27 keratin genes in the domain have been characterized transcriptionally.
58 citations
,
March 1985 in “Journal of The American Academy of Dermatology” This review discusses the historical, legal, and clinical aspects of electrolysis and thermolysis, highlighting potential risks due to the lack of standardized training for electrologists in the United States, but reports no new clinical results.
57 citations
,
April 2009 in “Differentiation” This study demonstrates that SDF-1/CXCL12 and CXCR4 signaling play a crucial role in directing the migration and positioning of melanoblasts in mouse hair follicle formation.
47 citations
,
July 1967 in “Science” This study observed morphological changes in scalp hair follicles of humans deprived of protein for 15 days, which suggests potential use in diagnosing protein-calorie malnutrition.
45 citations
,
April 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that Myc superfamily transcription factors may have distinct roles in different epithelial compartments of the human hair follicle, possibly influencing cell fate in the putative stem cell compartment.
43 citations
,
December 2006 in “The American journal of pathology” This study found that Edar signaling plays a role in regulating the hair cycle and apoptosis in hair follicle keratinocytes during the catagen phase in mice.
42 citations
,
September 2003 in “Journal of Investigative Dermatology” A missing mK6irs1 gene causes hair loss in mice.
40 citations
,
March 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study visualized mitochondrial metabolism in cultured bovine hair follicles and plucked human hairs, finding that ROS and mitochondrial polarization correlate in specific hair follicle regions, particularly near keratin deposition sites.
40 citations
,
January 2010 in “International Journal of Trichology” This review discusses the diagnostic criteria and guidelines for managing loose anagen syndrome and differentiating it from non-scarring alopecias, but it reports no new clinical results.
38 citations
,
November 1991 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin” Keratins 8 and 14 can help identify and diagnose benign skin tumors.