26 citations
,
October 2017 in “Scientific reports” This study found that a bacterial endophyte from Zea nicaraguensis effectively targets and colonizes plant root hair cells, promoting growth and solubilizing insoluble phosphorus for nutrient uptake.
12 citations
,
January 2018 in “PubMed” This study found that the ROCK inhibitor Y-27632 maintains self-renewal and stemness of hair follicle stem cells in vitro, supporting their potential for tissue engineering applications.
1 citations
,
September 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that miR-148a plays a significant role in regulating skin homeostasis and hair follicle cycling, influencing stem cell activity and development in mice.
March 2025 in “Molecules” This study found that Kyoh®, a flavonol-rich extract from rocket leaves, may promote hair growth by enhancing the expression of hair growth-related genes in laboratory conditions.
October 2010 in “Mayo Clinic women's healthsource” Dr. Rochelle Torgerson says female-pattern hair loss is often hereditary, starts after puberty, and can be slowed with treatments like Minoxidil. It can also indicate other health issues.
This study found that direct co-culture of human bone marrow-derived mesenchymal stromal cells with regulatory T cells enhanced osteogenic gene expression, alkaline phosphatase activity, and matrix mineralization, suggesting Treg's potential in promoting bone regeneration by modulating BMSC mechanobiology through the ROCK-myosin signaling pathway.
4 citations
,
May 1958 in “Journal of Investigative Dermatology” 253 citations
,
April 2008 in “Current opinion in cell biology” This study found that Notch signalling promotes differentiation of epidermal cells and acts as a tumour suppressor in the skin by interacting with various pathways and mechanisms.
47 citations
,
October 2020 in “Communications Biology” This study found that maintaining tension-force balance in a human skin equivalent improved characteristics of skin homeostasis and structure, suggesting potential as an alternative to animal models for studying skin physiology.
47 citations
,
February 2019 in “Asian Journal of Pharmaceutical and Clinical Research” This review discusses the chemical composition and traditional medicinal uses of Eruca sativa, particularly its potential applications in topical preparations for hair growth and treating skin infections, but reports no new clinical results.
35 citations
,
October 2014 in “Wound Repair and Regeneration” This study developed a validated murine model of hypertrophic scar contraction, demonstrating similarities to human skin and observing graft contraction and tissue characteristics over time.
18 citations
,
October 2013 in “Stem Cell Research & Therapy” This study found that combining polybrene and a ROCK inhibitor can effectively expand human keratinocyte stem/progenitor cells carrying a transgene, aiding their use in regenerative medicine.
16 citations
,
March 2021 in “Frontiers in cell and developmental biology” This study established an efficient short-term culture system for human hair follicle stem cells using human fibronectin and ROCK inhibitor Y-27632, enhancing cell proliferation and stemness for potential applications in hair follicle tissue engineering.
15 citations
,
August 2013 in “Stem Cells and Development” This study proposes a two-step method that may enhance the generation of stem-like epidermal cells with superior proliferation and differentiation potential for skin regeneration.
9 citations
,
March 2018 in “Actas Dermo-Sifiliográficas” This study found that the Spanish version of the Hair Specific Skindex 29 (HSS29) is a reliable and valid tool for assessing the quality of life impact of female androgenetic alopecia.
6 citations
,
July 2016 in “Gynecological Endocrinology” This study found that women with PCOS have higher total PSA levels than controls, and the total PSA level correlates positively with testosterone and free androgen index.
3 citations
,
May 2022 in “Experimental Dermatology” This review discusses the role of hair follicle stem cell metabolism, ageing, and microenvironment in hair growth disorders and compiles recent research on using stem cell-based regenerative medicine for treating alopecia, without reporting new clinical results.
2 citations
,
January 2025 in “Pharmaceutical Research” This article reviews the possible therapeutic activities of Angelica gigas Nakai root extracts and their components, noting their potential effects on neuro-cognitive, metabolic, and other health conditions, and reports no new clinical results.
2 citations
,
August 2023 in “The Journal of Animal and Plant Sciences” This study identified 1277 genomic regions selected for traits in indigenous Chinese goats, including cashmere fiber, reproduction, size, and high-altitude adaptation, revealing key candidate genes for these phenotypes through whole-genome resequencing.
2 citations
,
February 2020 in “Annual Research & Review in Biology” In this animal study, lavender oil, Eruca sativa oil, Aloe vera oil, and sodium carbonate decreased lipid levels and tumor markers in breast cancer models, suggesting potential benefits as adjunctive therapy during chemotherapy.
2 citations
,
January 2016 in “Advanced biomedical research” In this study, a hair wax containing propolis and Eruca sativa seed oil significantly improved hair growth in Wistar rats, increasing both the length and weight of newly grown hairs compared to controls.
April 2026 in “Academic Dermatology” In this retrospective observational study, researchers found that the Dean Scale showed better diagnostic accuracy than the CTCAE scale for detecting clinician-reported therapeutic responses to minoxidil in patients with anticancer therapy-induced alopecia, but both scales had limitations in recording clinically significant hair regrowth.
January 2023 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium” This study found that the novel culture condition gHFEM, which includes Y-27632 and bFGF, optimally promotes the proliferation and pluripotency of goat hair follicle stem cells in vitro.
November 2022 in “Journal of Investigative Dermatology” This study found that short-term treatment with ROCKi significantly increased keratinocyte stem cell proliferation without affecting their stemness, suggesting a potential safe approach for improving in vitro keratinocyte cultures for clinical applications.
April 2019 in “Journal of Investigative Dermatology” This study developed an Asian human sebocyte cell line from breast skin tissue that can be used for sebaceous gland biology investigations, showing that Y27632 may promote cell growth through EGFR-CRAF-MEK-ERK and AKT pathways.
April 2018 in “Journal of Investigative Dermatology” This study found that IL-9 influences the behavior of human primary keratinocytes by promoting motility while reducing invasion potential through a novel mechanism independent of matrix-metalloproteinases.
May 1993 in “Current problems in dermatology” This review discusses diagnostic approaches for childhood skin diseases with fever through clinical observations and covers recent advances in understanding the pathogenesis and epidemiology of related infections, without reporting new clinical results.
January 2022 in “The Egyptian Journal of Hospital Medicine” This study found that higher serum IL-21 levels may serve as a promising diagnostic and prognostic marker for alopecia areata, strongly correlating with disease activity.
April 2023 in “Journal of Investigative Dermatology” This study suggests that histological features of primary melanoma can partially predict lymph node metastasis using AI, achieving a best prediction AUROC of 0.65.
September 2023 in “Journal of the American Academy of Dermatology” This retrospective study found that among 20 pediatric patients in Rochester, MN, tinea capitis due to Trichophyton violaceum/soudanense presented with diverse scalp and body symptoms and suggested terbinafine may be more effective than griseofulvin for treatment.