Tissue-Scale Tensional Homeostasis in Skin Regulates Structure and Physiological Function

    October 2020 in “ Communications Biology ”
    Shun Kimura, Ayako Tsuchiya, Miho Ogawa … Takashi Tsuji
    Studysummary This study found that maintaining tension-force balance in a human skin equivalent improved characteristics of skin homeostasis and structure, suggesting potential as an alternative to animal models for studying skin physiology.
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    Research cited in this study 6

    1. Mechanical Forces in Skin Disorders Journal of Dermatological Science · 2018
    2. Planar Cell Polarity-Dependent and Independent Functions in the Emergence of Tissue-Scale Hair Follicle Patterns Developmental Biology · 2017
    3. Next Generation Human Skin Constructs as Advanced Tools for Drug Development Experimental Biology and Medicine · 2017
    4. Bioengineering a 3D Integumentary Organ System from iPS Cells Using an In Vivo Transplantation Model Science Advances · 2016
    5. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    6. Integument Pattern Formation Involves Genetic and Epigenetic Controls: Feather Arrays Simulated by Digital Hormone Models ˜The œInternational journal of developmental biology · 2004