research Selectively Targeting JAK1 or JAK3 Pathway Is Sufficient to Reverse Alopecia Areata
Blocking JAK1 or JAK3 helps reverse hair loss in a mouse model of alopecia areata.
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research Dermal Wnt/β-Catenin Activation Tunably Controls Hair Follicle Initiation
Activating Wnt in skin cells controls the number of hair follicles by directing cell movement and fate.
research The Role of Fgf20 in Establishing the Hair Follicle Dermal Condensate
Fgf20 is important for the development and regulation of the cells that form the base of hair follicles.
research Defining the Molecular Signature of the Hair Follicle Dermal Sheath and Its Functional Requirement for Hair Cycle Progression During Catagen
The hair follicle dermal sheath is essential for hair shedding and needs to communicate with the outer root sheath for normal hair growth cycles.
research Augmentation of HGF Signaling: Potential for Enhancing Hair Follicle Neogenesis and Development in Bioengineered Skin
Boosting HGF signaling could improve the creation of hair follicles in lab-made skin.
research Cell-Cell Interaction in the Hair Follicle Niche in Androgenetic Alopecia
New drug targets for hair loss treatment were identified by studying cell interactions in hair follicles.
research Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1
Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.
research Vertex and Occipital Intermediate and Terminal Hair Follicles from Androgenetic Alopecia Patients are Differentially Affected by Testosterone Ex Vivo
Occipital hair follicles in male pattern baldness respond uniquely to testosterone, not androgen-insensitive.
research Comprehensive Transcriptome Profiling Between Balding and Non-Balding Scalp of Female Pattern Hair Loss in Asian
SFRP2 and PTGDS may be key factors in female hair loss.
research Lineage Commitment of Dermal Fibroblast Progenitors Is Mediated by Chromatin De-repression
Skin cell types develop when specific genes are turned on by removing certain chemical tags from DNA.
research Application of Multi-Omics Techniques to Androgenetic Alopecia: Current Status and Perspectives
Multi-omics techniques help understand the molecular causes of androgenetic alopecia.
research Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein
Skin cells and certain hair follicle areas produce hemoglobin, which may help protect against oxidative stress like UV damage.
research Integrating Single-Cell and Spatial Transcriptomics of Human Hair Follicles to Define Transcriptional Signature of Follicular Dermal Papilla
The research identified specific genes that are active in the cells crucial for hair growth.
research Integrated Single-Cell Chromatin and Transcriptomic Analyses of Human Scalp Reveal Etiological Insights Into Genetic Risk for Hair and Skin Disease
The research provided new insights into the genetic factors contributing to hair loss and skin conditions by analyzing individual cells from the human scalp.
research Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds
The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.
research Stem Cell Dynamics, Migration, and Plasticity During Wound Healing
Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.
research Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice
Dermal adipose tissue in mice can change and revert to help with skin health.
research Dissecting Fibroblast Heterogeneity in Health and Fibrotic Disease
Different types of fibroblasts play various roles in both healthy and diseased tissues, and understanding them better could improve treatments for fibrotic diseases.
research Single-Cell Transcriptomic Analysis of Small and Large Wounds Reveals the Distinct Spatial Organization of Regenerative Fibroblasts
Different types of skin cells are organized in a special way in large wounds to help with healing and hair growth.
research Single-Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying
The study found new details about human hair growth and suggests that preventing a specific biological pathway could potentially treat hair graying.
research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla
Human nails and hair follicles have similar gene activity, especially in the cells that contribute to their growth and development.
research Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature
The research identified genes that explain why some sheep have curly wool and others have straight wool.
research Single-Cell Transcriptomics Reveals a Senescence-Associated IL-6/CCR6 Axis Driving Radiodermatitis
Blocking certain immune signals can reduce skin damage from radiation therapy.
research Autophagy Protects Murine Preputial Glands Against Premature Aging and Controls Their Sebum Phospholipid and Pheromone Profile
Autophagy prevents early aging and maintains lipid and pheromone balance in mouse glands.
research Defining the Transcriptional Signature of Esophageal-to-Skin Lineage Conversion
Adult esophageal cells can start to become like skin cells, with a key pathway influencing this change.
research Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing
The Aligned membranes improved wound healing and hair growth with a better immune response in mice.
research Single-Cell Transcriptome Sequence Profiling on the Morphogenesis of Secondary Hair Follicles in Ordos Fine-Wool Sheep
The research identifies genes linked to wool quality in sheep and provides insights to improve wool production.
research EGFR Marks a Subpopulation of Dermal Mesenchymal Cells Highly Expressing IGF1 Which Enhances Hair Follicle Regeneration
A certain type of skin cell, marked by EGFR, produces a lot of IGF1 and helps hair follicles grow back faster.
research Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision Between Stem Cell Maintenance and Differentiation
Sox9 levels in brain stem cells affect whether they stay as stem cells or become neurons.
research A Single-Cell Transcriptome Atlas During Cashmere Goat Hair Follicle Morphogenesis
The research mapped out the cell types and molecular processes involved in developing Cashmere goat hair follicles.