September 2018 in “International Journal of Advanced Community Medicine” This source describes the development of a new cream combining salicylic acid and retinol, assessed for its potential to alleviate itching in dermatitis and treat acne vulgaris, with stability and patch testing indicating no irritation or allergic reactions.
This study introduces a novel pro-drug formulation of all-trans retinoic acid that reduces skin inflammation and achieves sustained drug release over several days compared to traditional methods.
This article reviews various cosmetic and skincare products used in dermatology for preventive and treatment purposes, highlighting their role in conditions such as atopic dermatitis, photoaging, and male pattern baldness, but reports no new results.
December 2015 in “Focus on catalysts” This study found that Pomiferin demonstrated potent stimulation of extracellular matrix proteins in human dermal fibroblasts and hair follicles, suggesting its potential as an ingredient in skin and scalp treatments.
January 2009 in “Journal of Zhengzhou University” This study found that lipid and acne inhibitive cream improved the skin condition in a rabbit ear acne model, showing significant changes in follicular cornification.
This study found that Scalp med®, a solution including minoxidil, significantly improved hair count and thickness in men with androgenetic alopecia after 24 weeks of treatment.
This study found that the enzyme encoded by Dgat1 acts as a retinol acyltransferase in murine epidermis, protecting against retinoid toxicity and alopecia by preventing retinol accumulation.
May 2001 in “Journal of Investigative Dermatology” In this study, Maas-Szabowski and Szabowski revealed that c-Jun and JunB transcription factors, as well as granulocyte macrophage-colony stimulating factor, regulate human keratinocyte growth and differentiation in fibroblast–keratinocyte interactions.
September 1988 in “Inpharma (Balgowlah)” Retinoids are effective for acne but can cause serious side effects.
May 1961 in “Tumori Journal” This study found that vitamin A treatment in rats reduced hyperplastic-dysplastic changes and sebaceous gland hypertrophy associated with 3,4-benzpyrene-induced tumors.
January 2008 in “Journal of Clinical Dermatology” This study found that a new topical agent, Scalp medⓇ, significantly improved hair count and thickness in men with androgenetic alopecia after 24 weeks of treatment.
4 citations
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October 2003 in “PubMed” This study in a rat model found that dietary rehabilitation with a high protein diet reversed symptoms of kwashiorkor, suggesting a role for free radicals in its development.
7 citations
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January 1991 in “Comparative biochemistry and physiology. A. Comparative physiology” This study found that a dietary change in common marmosets significantly reduced in vitro erythrocyte haemolysis, improved skin lesions, and promoted complete fur regrowth, possibly due to increased vitamin E levels.
January 2018 in “Investigative Ophthalmology & Visual Science” This study observed retinal and optic nerve damage in patients who had taken finasteride, suggesting potential ocular toxicity associated with the drug's use.
31 citations
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November 2014 in “Investigative Ophthalmology & Visual Science” This study reported that in rat retinas under high pressure, allopregnanolone synthesis increased and helped reduce pressure-induced damage through GABAA receptors, suggesting potential therapeutic use in glaucoma.
232 citations
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January 2002 in “Mechanisms of development” This study reports that the differential expression patterns of three retinaldehyde dehydrogenases suggest a regulated need for retinoic acid synthesis in various organs during late mouse organogenesis.
April 2017 in “Journal of Investigative Dermatology” This study found that retinoic acid and a retinol complex formulation showed different permeation and compound localization in a skin equivalent model, with unique lipid changes observed with only the retinol formulation.
April 2025 in “Experimental Eye Research” In this study, researchers characterized the retinal structure and function of the Oatrhg mouse model of gyrate atrophy, finding localized atrophy without significant retina-wide functional impact, suggesting the model may be useful for testing new treatments using multimodal retinal imaging.
58 citations
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February 2016 in “Scientific reports” This study found that dual inhibition of BACE1 and BACE2 in mice affects melanosome maturation and causes dose-dependent hair depigmentation without altering retinal morphology.
15 citations
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May 1987 in “Fundamental and applied toxicology” This study found that SMR-2 and SMR-6, analogs of retinoic acid and retinol, were approximately 100 times more toxic than retinoic acid in mice, inducing hypervitaminosis A and affecting various organs and tissues.
1 citations
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October 2025 in “Ophthalmology Science” In this experimental study, researchers found that intravitreal injections of up to 100μg of topotecan in rabbits caused no systemic or ocular toxicity, while 200μg doses resulted in localized retinal changes and decreased electroretinography amplitudes near the injection site.
1 citations
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November 2024 in “Romanian Journal of Morphology and Embryology” This overview examines the biology, origin, structure, and function of various cells and structures, such as the blood-retinal barrier and Merkel cells, and discusses their roles in disease pathogenesis, along with recent findings related to the lymph nodes' paracortex.
October 2024 in “Developmental Dynamics” This paper highlights advances in Developmental Dynamics, noting how epoa-deficient zebrafish can model Diamond-Blackfan anemia like disorders for drug screening, Alx4 mouse models offer insights into craniofacial development, and mTORC1 signaling is crucial for retinal development.
August 2024 in “Case Reports in Ophthalmology” In this case report, researchers observed that local radiation therapy to the orbits may not be sufficient to halt progression of new retinal lesions in older patients, even when the disease initially appears confined to the intraocular space.
November 2017 in “Journal of Surgical Academia” This case report describes a woman with systemic lupus erythematosus who developed non-progressive visual field defects after hypertensive retinopathy, with cotton wool spots indicating retinal nerve fiber microinfarctions.
In this study, researchers used two dermal papilla spheroid models to investigate hair cycle regression mechanisms and found that the vascular system enhances tissue physiology and gene modulation, while Retinol-based treatments can partially recover tissue degeneration observed over an extended culture period.
59 citations
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January 2011 in “Retina-the Journal of Retinal and Vitreous Diseases” This study suggests that finasteride may be a promising treatment for chronic central serous chorioretinopathy, but larger controlled trials are needed to confirm its efficacy.
9 citations
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January 2020 This case series observed that macular changes from popper use can resolve completely after cessation, even in individuals with chronic use.
April 2024 in “Indian journal of ophthalmology. Case reports” This study reports a case of acute central serous chorioretinopathy potentially linked to prolonged topical minoxidil use for alopecia, with improvement following cessation of the treatment.
5 citations
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January 2017 in “Arquivos Brasileiros de Oftalmologia” This report describes a novel mutation in the CDH3 gene in an 11-year-old Iranian boy with hypotrichosis and juvenile macular dystrophy, indicating a new genetic variant associated with the disorder.