July 1989 in “British Journal of Dermatology” Long-term use of canthaxanthin may cause reversible changes in the eye, including crystal deposits and altered vision responses.
April 2024 in “International journal of women's health” This review explores adult female acne, focusing on its multifactorial causes, treatment options, and impact on quality of life, but reports no new clinical results.
February 2024 in “Skin health and disease” This source reviews popular cosmeceutical ingredients for skin care, noting that while they are popular among consumers for anti-aging benefits, many lack robust clinical evidence for their efficacy and safety, as they are not regulated by the FDA.
June 2023 in “University of Thi-Qar Journal of Science” This review discusses the various uses of retinoids, derived from vitamin A, in cosmetic and dermatological treatments for conditions like acne, psoriasis, and skin aging. The authors emphasize retinoids' limited use due to their susceptibility to degradation and safety concerns, particularly with retinoic acid.
December 2025 in “Open Repository of the University of Porto (University of Porto)” Pharmacists play a crucial role in improving patient outcomes through personalized care and staying updated with scientific advancements.
September 1998 in “Journal of The European Academy of Dermatology and Venereology” Phototrichogram helps assess hair loss severity.
77 citations
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April 1968 in “Development” This study found that excess vitamin A in organotypic cultures of embryonic mouse skin led to abnormal hair follicle development and glandular metaplasia, unlike in untreated controls that showed normal differentiation.
75 citations
,
September 2009 in “Dermato-endocrinology” This review discusses the skin's role in producing hormones and related substances, highlighting their potential in homeostasis and disease management, and reports no new clinical findings.
56 citations
,
November 2003 in “Journal of Investigative Dermatology” This study identified altered expression of MMP-19 in the skin's epidermal layers during diseases like psoriasis and eczema, implying a role in disease processes.
52 citations
,
May 1982 in “The American journal of the medical sciences” This study found that the most likely cause of hypercalcemia in a patient with symptoms of hypervitaminosis A and a history of chronic vitamin A ingestion was vitamin A toxicity.
45 citations
,
August 1954 in “Experimental Biology and Medicine” This study found that vitamin A dissolved in alcohol penetrates skin quickly and does not impair hair growth, even in large doses, but it does not retard keratinization unlike when dissolved in fatty acids.
39 citations
,
June 2009 in “Oncology” This study observed that high-dose retinol palmitate was well-tolerated in resected stage I lung cancer patients, though it raised concerns about potential impacts on lipid metabolism due to elevated gamma-GT levels and triglycerides.
34 citations
,
January 2022 in “Molecules/Molecules online/Molecules annual” This review highlights the use of natural products in cosmetic-containing herbals for skin and hair care but reports no new clinical results, calling attention to their claimed curative properties and minimal side effects.
20 citations
,
February 1977 in “The anatomical record” This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.
18 citations
,
January 2016 in “Elsevier eBooks” This chapter reviews nanotechnology in cosmetics, detailing various formulations, performance assessment methods, and evolving regulations, while discussing safety, stability, and effectiveness concerns; it reports no new experimental results.
18 citations
,
March 1992 in “Archives of Dermatology” This case report presents a 28-year-old man with scarring alopecia unresponsive to topical treatments, alongside a family history of keratosis pilaris and unique curly scalp hair.
18 citations
,
October 1978 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that excess vitamin A induced stable glandular morphogenesis and mucous metaplasia in embryonic mouse vibrissa follicles, even after switching to standard medium.
16 citations
,
November 2020 in “PLOS ONE” This study found that lack of sleep, increased physical activity, and alopecia were associated with a higher risk of COVID-19 infection, while low-dose alcohol intake, hand hygiene, and daily fruit consumption were linked to reduced morbidity.
10 citations
,
February 2014 in “Fitoterapia” This study found that Pomiferin may effectively stimulate extracellular matrix protein expression in skin and scalp models, with results comparable to retinol, suggesting potential as a topical treatment ingredient.
5 citations
,
October 2021 in “Clinical, cosmetic and investigational dermatology” In this study, Japanese patients with alopecia areata were found to have higher BMI and retinol intake, with retinol intake predicting severity of hair loss.
5 citations
,
September 2013 in “BMB Reports” In this study, the anti-wrinkle effect of bone morphogenetic protein receptor 1a extracellular domain was significantly greater than that of retinoic acid in a mouse model, suggesting potential for BMP antagonists in skin or hair treatments.
4 citations
,
February 2022 in “Frontiers in molecular biosciences” This study revealed that chronic restraint stress in mice led to significant alterations in metabolic pathways and gene expression associated with hair growth inhibition, using metabolomics and transcriptomics analyses.
4 citations
,
November 2021 in “Frontiers in Cell and Developmental Biology” Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.
1 citations
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April 2015 in “The FASEB journal” In this study using SKH-1 mice, researchers observed that acute UVB exposure increased expression of retinoid metabolism proteins and decreased retinol storage enzyme levels, suggesting enhanced retinoic acid synthesis in the epidermis.
February 2026 in “Trials” The Exfoliate-Dissolve-Repair skincare approach may effectively treat keratosis pilaris and reduce the need for corticosteroids.
July 2024 in “Journal of Investigative Dermatology” The new skin organoid system effectively mimics human skin for studying its functions, injuries, and diseases.
July 2024 in “DOAJ (DOAJ: Directory of Open Access Journals)” This article reviews the effects of vitamins, including A, C, D, E, and B, on animal fur, highlighting their roles in promoting healthy skin and fur condition by regulating cell renewal, metabolism, and collagen synthesis.
This study using Mendelian randomization found that higher levels of circulating β-carotene and α-tocopherol may reduce the risk of androgenetic alopecia, while α-tocopherol may also protect against alopecia areata, suggesting diet-derived antioxidants could aid in preventing non-scarring alopecia.
April 2023 in “Journal of Investigative Dermatology” In this study, recombinant type III collagen was found to promote fibroblast proliferation and migration, suggesting potential anti-aging and repairing effects, although it was only effective in significantly inhibiting IL-6, not TNF-α, secretion.
October 2021 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study found that Japanese patients with alopecia areata had higher body mass index and retinol intake, with retinol intake being a predictor of hair loss severity.