The Stability of Vitamin A-Induced Metaplasia of Mouse Vibrissa Follicles In Vitro

    October 1978 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Margaret H. Hardy, C. G. Bellows
    TLDR Excess vitamin A causes lasting gland changes in mouse hair follicles.
    The study tested the stability of glandular morphogenesis and mucous metaplasia in embryonic mouse vibrissa follicles induced by excess vitamin A in vitro. Observations showed that 13.5-day embryonic upper lip skin formed branching glands secreting mucus after 10-14 days in a medium with 4.7 microgram/ml retinol. Even when switched to standard medium after 7 days, glandular changes persisted, though some hair follicles reverted to their original state. Similar persistence was noted in 13-day embryos treated with 6.0 microgram/ml vitamin A for 3 days. The addition of high-dose cortisol did not alter the moderate glandular morphogenesis in 15-day skin. The study suggested that glandular morphogenesis initiation in mouse follicles by vitamin A is akin to a new secondary embryonic induction rather than epithelial modulation.
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