Anti-Wrinkle Effect of Bone Morphogenetic Protein Receptor 1a Extracellular Domain (BMPR1a-ECD)

September 2013 in “ BMB Reports ”

Byung Hak Yoon, Yun Hui Jeon, Byung‐Hee Hwang, Hyuk Nam Kwon, Sen Yon Choe, Zung Yoon Yang

BMPR1a-ECD bone morphogenetic protein receptor 1a-extracellular domain MMP collagen synthesis retinoic acid UVB-induced epidermal thickening procollagen loss retinol UVB

TLDR BMPR1a-ECD reduces wrinkles much more effectively than retinoic acid.

The study investigated the anti-wrinkle effects of BMPR1a-ECD in a mouse model, finding that it significantly reduced wrinkle formation by inhibiting MMP expression and increasing collagen synthesis. BMPR1a-ECD showed a 6-fold stronger anti-wrinkle effect than retinoic acid and prevented UVB-induced epidermal thickening and procollagen loss. The results suggested that BMPR1a-ECD could be a promising therapeutic agent for treating skin wrinkles and potentially other skin or hair diseases, with further studies recommended to explore its mechanisms and applications.

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Anti-Wrinkle Effect of Bone Morphogenetic Protein Receptor 1a Extracellular Domain (BMPR1a-ECD)

Research cited in this study

research Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

research The Hair Follicle as a Dynamic Mini-Organ

research Skin Aging

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