Effects of Lipid and Acne Inhibitive Cream on Acne Model of Rabbit's Ears

    January 2009 in “ Journal of Zhengzhou University ”
    Wenzhi Yang
    From the encyclopedia
    oleic acid →
    Tretinoin →

    the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

    retinoic acid →
    Studysummary This study found that lipid and acne inhibitive cream improved the skin condition in a rabbit ear acne model, showing significant changes in follicular cornification.
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    The study aimed to observe the effects of lipid and acne inhibitive cream (LAIC) on an acne model in rabbit ears. Sixteen New Zealand white rabbits were divided into experimental and control groups, with oleic acid used to induce acne. The experimental group received LAIC treatment, while the control group received tretinoin cream. Results showed that LAIC improved the skin condition by making it thinner and softer, reducing corneous plugs, and relieving papules. Histologically, LAIC reduced cuticle thickness and mildly expanded follicular orifices. Both groups showed significant improvements before and after treatment, but there was no significant difference between the two groups. The study concluded that LAIC could improve abnormal cornification of hair follicles in acne.
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