The Effect of Dietary Change on In Vitro Erythrocyte Hemolysis, Skin Lesions, and Alopecia in Common Marmosets (Callithrix Jacchus)
January 1991
in “
Comparative biochemistry and physiology. A. Comparative physiology
”
alopecia skin lesions vitamin E n-3 long chain polyunsaturated fatty acids α-tocopherol all-trans retinol total lipid fibrinogen neutrophil erythrocyte haemolysis oxidative stress membrane n-6: n-3 balance hair loss skin problems vitamin E omega-3 fatty acids vitamin A blood fat blood clotting protein white blood cells red blood cell breakdown oxidative damage fatty acid balance
TLDR A diet high in vitamin E improved blood health, skin, and fur in common marmosets.
The study investigated the impact of a dietary change on common marmosets (Callithrix jacchus) with high in vitro erythrocyte haemolysis, skin lesions, and alopecia. The diet was low in lipid, high in vitamin E, and lacked n-3 long chain polyunsaturated fatty acids. Significant increases were observed in plasma α-tocopherol (vitamin E), all-trans retinol (vitamin A), and total lipid concentrations, while fibrinogen concentration and neutrophil count decreased. In vitro erythrocyte haemolysis dropped from 64% to less than 2%, and there was a complete regression of skin lesions and alopecia with full fur regrowth. The improvements were attributed to high circulating vitamin E, which protected against oxidative stress and corrected the membrane n-6: n-3 balance.
